Insulin Resistance in a Young Man With Cystic Fibrosis

Mitchell E. Geffner, Barbara M. Lippe, Robert M. Itami, Solomon A. Kaplan, Baiba K. Gillard, Seymour R. Levin, Ian L. Taylor

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

An 18-year-old man had cystic fibrosis (CF) and insulin-resistant carbohydrate intolerance characterized by (1) obesity, basal hyperinsulinemia, and hyperglucagonemia; (2) impaired oral glucose tolerance; (3) hyperinsulinemia in response to oral and intravenous (IV) administration of glucose and to IV administration of tolbutamide; (4) exaggerated gastric inhibitory polypeptide secretion following orally administered glucose; (5) diminished sensitivity to insulin administered IV compared with other patients with CF. Both parents also demonstrate basal and stimulated hyperinsulinemia in response to orally administered glucose. The long-term outlook for patients with CF is improving, and more patients are surviving childhood. Thus, it should be recognized that an insulin-resistant form of carbohydrate intolerance may develop in patients with CF with obesity and/or genetic risk factors.

Original languageEnglish (US)
Pages (from-to)677-680
Number of pages4
JournalAmerican Journal of Diseases of Children
Volume138
Issue number7
DOIs
StatePublished - Jul 1984

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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