Insulin-like growth factor binding proteins in autoimmune diseases

Huihua Ding, Tianfu Wu

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Insulin-like growth factor binding proteins (IGFBPs) are a family of proteins binding to Insulin-like growth factors (IGFs), generally including IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP5, and IGFBP6. The biological functions of IGFBPs can be classified as IGFs-dependent actions and IGFs-independent effects. In this review, we will discuss the structure and function of various IGFBPs, particularly IGFBPs as potential emerging biomarkers and therapeutic targets in various autoimmune diseases, and the possible mechanisms by which IGFBPs act on the pathogenesis of autoimmune diseases.

Original languageEnglish (US)
Article number499
JournalFrontiers in Endocrinology
Volume9
Issue numberAUG
DOIs
StatePublished - Aug 30 2018

Keywords

  • Autoimmune diseases
  • Biomarkers
  • IGFBPs
  • Metabolism
  • Therapeutic targets

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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