Insight into the mechanisms of action of estrogen receptor β in the breast, prostate, colon, and CNS

Prasenjit Dey, Rodrigo P.A. Barros, Margaret Warner, Anders Ström, Jan-Ake Gustafsson

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

Estrogen and its receptors (ERs) influence many biological processes in physiology and pathology in men and women. ERs are involved in the etiology and/or progression of cancers of the prostate, breast, uterus, ovary, colon, lung, stomach, and malignancies of the immune system. In estrogen-sensitive malignancies, ERβ usually is a tumor suppressor and ERα is an oncogene. ERβ regulates genes in several key pathways including tumor suppression (p53, PTEN); metabolism (PI3K); survival (Akt); proliferation pathways (p45Skp2, cMyc, and cyclin E); cell-cycle arresting factors (p21WAF1, cyclin-dependent kinase inhibitor 1 (CDKN1A)), p27Kip1, and cyclin-dependent kinases (CDKs); protection from reactive oxygen species, glutathione peroxidase. Because they are activated by small molecules, ERs are excellent targets for pharmaceuticals. ERα antagonists have been used for many years in the treatment of breast cancer and more recently pharmaceutical companies have produced agonists which are very selective for ERα or ERβ. ERβ agonists are being considered for preventing progression of cancer, treatment of anxiety and depression, as anti-inflammatory agents and as agents, which prevent or reduce the severity of neurodegenerative diseases.

Original languageEnglish (US)
JournalJournal of Molecular Endocrinology
Volume51
Issue number3
DOIs
StatePublished - Sep 12 2013

Keywords

  • 3β-Adiol
  • Anti-proliferative
  • Cell cycle
  • Estrogen receptors

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology

Fingerprint

Dive into the research topics of 'Insight into the mechanisms of action of estrogen receptor β in the breast, prostate, colon, and CNS'. Together they form a unique fingerprint.

Cite this