Insidious pathogen-mimicking properties of nanoparticles in triggering the lectin pathway of the complement system

S. Moein Moghimi; Peter P. Wibroe; Linping Wu; Z. Shadi Farhangrazi

doi:10.1515/ejnm-2015-0014

Insidious pathogen-mimicking properties of nanoparticles in triggering the lectin pathway of the complement system

S. Moein Moghimi, Peter P. Wibroe, Linping Wu, Z. Shadi Farhangrazi

Research output: Contribution to journal › Review article

4 Scopus citations

Abstract

The lectin pathway of the complement system is an integral component of the innate immune system recognizing pathogens through patterns of sugar moieties displayed on their surfaces and neutralizing them through an antibody-independent reaction cascade. Many engineered nanoparticles incite complement through the lectin pathway, but these nanoparticles inherently do not express surface-exposed sugars. However, the projected polymeric surface architecture of nanoparticles may transiently resemble structural motifs of peptidoglycan constituents of pathogens and trigger the lectin pathway. We discuss these issues in relation to nanomedicine design and immune safety.

Original language	English (US)
Pages (from-to)	263-268
Number of pages	6
Journal	European Journal of Nanomedicine
Volume	7
Issue number	3
DOIs	https://doi.org/10.1515/ejnm-2015-0014
State	Published - Jun 1 2015

Keywords

drug delivery
infusion-related reactions
innate immunity
nanomedicine
nanoparticles
polymers

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
Physical and Theoretical Chemistry

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abstract = "The lectin pathway of the complement system is an integral component of the innate immune system recognizing pathogens through patterns of sugar moieties displayed on their surfaces and neutralizing them through an antibody-independent reaction cascade. Many engineered nanoparticles incite complement through the lectin pathway, but these nanoparticles inherently do not express surface-exposed sugars. However, the projected polymeric surface architecture of nanoparticles may transiently resemble structural motifs of peptidoglycan constituents of pathogens and trigger the lectin pathway. We discuss these issues in relation to nanomedicine design and immune safety.",

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AU - Wibroe, Peter P.

AU - Wu, Linping

AU - Farhangrazi, Z. Shadi

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AB - The lectin pathway of the complement system is an integral component of the innate immune system recognizing pathogens through patterns of sugar moieties displayed on their surfaces and neutralizing them through an antibody-independent reaction cascade. Many engineered nanoparticles incite complement through the lectin pathway, but these nanoparticles inherently do not express surface-exposed sugars. However, the projected polymeric surface architecture of nanoparticles may transiently resemble structural motifs of peptidoglycan constituents of pathogens and trigger the lectin pathway. We discuss these issues in relation to nanomedicine design and immune safety.

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KW - innate immunity

KW - nanomedicine

KW - nanoparticles

KW - polymers

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