Innovative magnetic scaffolds for orthopedic tissue engineering

S. Panseri; A. Russo; G. Giavaresi; M. Sartori; F. Veronesi; M. Fini; D. M. Salter; A. Ortolani; A. Strazzari; A. Visani; C. Dionigi; N. Bock; M. Sandri; A. Tampieri; M. Marcacci

doi:10.1002/jbm.a.34167

Innovative magnetic scaffolds for orthopedic tissue engineering

S. Panseri, A. Russo, G. Giavaresi, M. Sartori, F. Veronesi, M. Fini, D. M. Salter, A. Ortolani, A. Strazzari, A. Visani, C. Dionigi, N. Bock, M. Sandri, A. Tampieri, M. Marcacci

Houston Methodist

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

The use of magnetism in tissue engineering is a very promising approach, in fact magnetic scaffolds are able not only to support tissue regeneration, but they can be activated and work like a magnet attracting functionalized magnetic nanoparticles (MNPs) injected close to the scaffold enhancing tissue regeneration. This study aimed to assess the in vivo biocompatibility and osteointegrative properties of novel magnetic scaffolds. Two hydroxyapatite/collagen (70/30 wt %) magnetic scaffolds were magnetized with two different techniques: direct nucleation of biomimetic phase and superparamagnetic nanoparticles (MNPs) on self-assembling collagen fibers (MAG-A) and scaffold impregnation in ferro-fluid solution (MAG-B). Magnetic scaffolds were implanted in rabbit distal femoral epiphysis and tibial mid-diaphysis. Histopathological screening showed no inflammatory reaction due to MNPs. Significantly higher bone healing rate (ΔBHR) results were observed in MAG-A in comparison to MAG-B. Significant differences were also found between experimental times with an increase in ΔBHR from 2 to 4 weeks for both scaffolds in trabecular bone, while only for MAG-B (23%, p < 0.05) in cortical bone. The proposed magnetic scaffolds seem to be promising for magnetic guiding in orthopedic tissue engineering applications and they will be suitable to treat also several pathologies in regenerative medicine area.

Original language	English (US)
Pages (from-to)	2278-2286
Number of pages	9
Journal	Journal of Biomedical Materials Research - Part A
Volume	100 A
Issue number	9
DOIs	https://doi.org/10.1002/jbm.a.34167
State	Published - Sep 2012

Keywords

in vivo biocompatibility
magnetic nanoparticles
orthopedic tissue engineering
regenerative medicine
scaffolds

ASJC Scopus subject areas

Biomedical Engineering
Biomaterials
Ceramics and Composites
Metals and Alloys

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Panseri, S., Russo, A., Giavaresi, G., Sartori, M., Veronesi, F., Fini, M., Salter, D. M., Ortolani, A., Strazzari, A., Visani, A., Dionigi, C., Bock, N., Sandri, M., Tampieri, A., & Marcacci, M. (2012). Innovative magnetic scaffolds for orthopedic tissue engineering. Journal of Biomedical Materials Research - Part A, 100 A(9), 2278-2286. https://doi.org/10.1002/jbm.a.34167

Panseri, S, Russo, A, Giavaresi, G, Sartori, M, Veronesi, F, Fini, M, Salter, DM, Ortolani, A, Strazzari, A, Visani, A, Dionigi, C, Bock, N, Sandri, M, Tampieri, A & Marcacci, M 2012, 'Innovative magnetic scaffolds for orthopedic tissue engineering', Journal of Biomedical Materials Research - Part A, vol. 100 A, no. 9, pp. 2278-2286. https://doi.org/10.1002/jbm.a.34167

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abstract = "The use of magnetism in tissue engineering is a very promising approach, in fact magnetic scaffolds are able not only to support tissue regeneration, but they can be activated and work like a magnet attracting functionalized magnetic nanoparticles (MNPs) injected close to the scaffold enhancing tissue regeneration. This study aimed to assess the in vivo biocompatibility and osteointegrative properties of novel magnetic scaffolds. Two hydroxyapatite/collagen (70/30 wt %) magnetic scaffolds were magnetized with two different techniques: direct nucleation of biomimetic phase and superparamagnetic nanoparticles (MNPs) on self-assembling collagen fibers (MAG-A) and scaffold impregnation in ferro-fluid solution (MAG-B). Magnetic scaffolds were implanted in rabbit distal femoral epiphysis and tibial mid-diaphysis. Histopathological screening showed no inflammatory reaction due to MNPs. Significantly higher bone healing rate (ΔBHR) results were observed in MAG-A in comparison to MAG-B. Significant differences were also found between experimental times with an increase in ΔBHR from 2 to 4 weeks for both scaffolds in trabecular bone, while only for MAG-B (23%, p < 0.05) in cortical bone. The proposed magnetic scaffolds seem to be promising for magnetic guiding in orthopedic tissue engineering applications and they will be suitable to treat also several pathologies in regenerative medicine area.",

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AU - Ortolani, A.

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AU - Visani, A.

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AU - Bock, N.

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Innovative magnetic scaffolds for orthopedic tissue engineering

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Keywords

ASJC Scopus subject areas

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