TY - JOUR
T1 - Innovations in avoiding particle clearance from blood by Kupffer cells
T2 - Cause for reflection
AU - Moghimi, Seyed
AU - Davis, S. S.
PY - 1994/12/1
Y1 - 1994/12/1
N2 - Therapeutic applications of drug carrier systems following intravenous administration have been limited because of the pronounced tendency of these carriers to localize primarily in Kupffer cells. Recently, attempts have been made to design colloids and drug carrier systems that can be disguised as 'self' and remain unrecognizable, at least to a certain extent, by the hepatic macrophages. This review is designed to provide a critical view on fundamentals, current progress, limitations, and future prospects of such engineered colloids and drug carrier systems for intravenous route of administration.
AB - Therapeutic applications of drug carrier systems following intravenous administration have been limited because of the pronounced tendency of these carriers to localize primarily in Kupffer cells. Recently, attempts have been made to design colloids and drug carrier systems that can be disguised as 'self' and remain unrecognizable, at least to a certain extent, by the hepatic macrophages. This review is designed to provide a critical view on fundamentals, current progress, limitations, and future prospects of such engineered colloids and drug carrier systems for intravenous route of administration.
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M3 - Article
C2 - 7704918
AN - SCOPUS:0028631169
SN - 0743-4863
VL - 11
SP - 31
EP - 59
JO - Critical Reviews in Therapeutic Drug Carrier Systems
JF - Critical Reviews in Therapeutic Drug Carrier Systems
IS - 1
ER -