Innate immune signaling and negative regulators in cancer

Helen Yicheng Wang, Rongfu Wang

Research output: Chapter in Book/Report/Conference proceedingChapter


Innate immune pattern recognition receptors (PRRs), including Toll-like receptors (TLRs), NOD-like receptors (NLRs), RIG-I-like receptors, and AIM2-like receptors (ALRs), function as pathogen pattern recognition molecules that sensor and initiate innate and adaptive immune responses against microbes and cancer cells. Recognition of pathogen-derived ligands by PRRs expressed on many types of cells, including dendritic cells (DCs) and T cells, triggers the NF-kB, type 1 interferon and inflammasome activation pathways, leading to the production of proinflammatory cytokines that are essential in inflammation and inflammation-linked cancer. Both positive and negative regulators are critical in the maintenance of innate immune homeostasis. In this review, I focus on the current understanding of PRRs, signaling pathways and their regulation through negative regulators. Their relevance to cancer will be discussed as well.

Original languageEnglish (US)
Title of host publicationInnate Immune Regulation and Cancer Immunotherapy
PublisherSpringer New York
Number of pages28
ISBN (Print)9781441999146, 9781441999139
StatePublished - Jan 1 2012

ASJC Scopus subject areas

  • Medicine(all)


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