TY - JOUR
T1 - Injectable Porous Silicon Nanoparticles as a Plasma Cytokine Scavenger for Potentiating Cytokine Storm Syndrome Treatment
AU - Qi, Ruogu
AU - Li, Shengliang
AU - Li, Feng
AU - Mai, Junhua
AU - Wang, Yu
AU - Zhu, Guixian
AU - Zhang, Dechen
AU - Li, Zheng
AU - Shen, Haifa
AU - Shen, Jianliang
AU - Liu, Xuewu
N1 - Funding Information:
This work was sponsored by Ntercept, LLC, through Houston Methodist Research Institute. R.Q. was partially supported by the Jiangsu Specially Appointed Professor Talent Program.
Publisher Copyright:
© 2023 The Authors. Advanced NanoBiomed Research published by Wiley-VCH GmbH.
PY - 2023/10
Y1 - 2023/10
N2 - Scavenging excessively secreted cytokines from plasma is vital for treating cytokine storm syndrome (CSS). Therefore, appropriate adsorbent materials are highly desired for efficient and selectively capturing the plasma cytokines. For this purpose, injectable porous silicon particles (PSPs) are designed as scavenging adsorbents. The fabricated PSP features high porosity for large pore volume and high specific surface area. Polyethylene glycol is coated on the outer surface of PSP for a longer body circulation time, while antibodies are immobilized on the interior surface of PSP for the specific recognition of targeting biomacromolecules. The resultant injectable scavengers demonstrate satisfactory performance for sequestering tumor necrosis factor (TNF) or TNF receptor (TNFR) in serum and in?vivo. The salient biocompatibility of the preparing scavenger is demonstrated through simulative hemoperfusion experiments and in?vivo toxicology tests. Importantly, the scavengers are injected into mice like a drug to rapidly remove blood-circulating endogenous TNFR. These features together with its facile fabrication present the silicon-based porous particles as candidates in clinical application for relieving the infection-induced CSS.
AB - Scavenging excessively secreted cytokines from plasma is vital for treating cytokine storm syndrome (CSS). Therefore, appropriate adsorbent materials are highly desired for efficient and selectively capturing the plasma cytokines. For this purpose, injectable porous silicon particles (PSPs) are designed as scavenging adsorbents. The fabricated PSP features high porosity for large pore volume and high specific surface area. Polyethylene glycol is coated on the outer surface of PSP for a longer body circulation time, while antibodies are immobilized on the interior surface of PSP for the specific recognition of targeting biomacromolecules. The resultant injectable scavengers demonstrate satisfactory performance for sequestering tumor necrosis factor (TNF) or TNF receptor (TNFR) in serum and in?vivo. The salient biocompatibility of the preparing scavenger is demonstrated through simulative hemoperfusion experiments and in?vivo toxicology tests. Importantly, the scavengers are injected into mice like a drug to rapidly remove blood-circulating endogenous TNFR. These features together with its facile fabrication present the silicon-based porous particles as candidates in clinical application for relieving the infection-induced CSS.
KW - porous silicon particles
KW - adsorbent materials
KW - cytokine scavenger
KW - cytokine storm syndrome relief
KW - injectable particles
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U2 - 10.1002/anbr.202300037
DO - 10.1002/anbr.202300037
M3 - Article
SN - 2699-9307
VL - 3
JO - Advanced NanoBiomed Research
JF - Advanced NanoBiomed Research
IS - 10
M1 - 2300037
ER -