@inbook{c3e93ee364cc49dda4a4ef57b8198c0f,
title = "Injectable Multistage Nanovectors for Enhancing Imaging Contrast and Directed Therapy",
abstract = "Nanovectors are powerful tools for the systemic delivery of therapeutic and imaging agents in oncology. We have recently introduced multistage nanovectors (MSV), designed to overcome sequential biological barriers. The first stage, comprised of porous silicon microparticles, targets tumor-associated endothelium. Once arrested at the disease site, second-stage nanoparticles carrying the therapeutic and imaging agents are released into the tumor microenvironment by time-dependent degradation of the silicon carrier. Particles–cell interactions and degradation of MSV can be controlled by means of particle surface modifications. In this chapter, we will describe studies related to the MSV, focusing on fabrication, intracellular multisite trafficking, advanced therapeutic systems, and contrast agents.",
keywords = "Hydrogen Fluoride, Iron Oxide Nanoparticles, Porous Silicon, Silicon Nitride, Silicon Particle",
author = "Biana Godin and Rita Serda and Xuewu Liu and Mauro Ferrari",
note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media, LLC 2012.",
year = "2012",
doi = "10.1007/978-1-4614-2305-8\_10",
language = "English (US)",
isbn = "978-1-4614-2304-1",
series = "Nanostructure Science and Technology",
publisher = "Springer Publishing Company",
pages = "201--223",
booktitle = "Nanostructure Science and Technology",
address = "United States",
}