Injectable Hexapeptide Hydrogel for Localized Chemotherapy Prevents Breast Cancer Recurrence

Yingqiu Qi; Huan Min; Ayeesha Mujeeb; Yinlong Zhang; Xuexiang Han; Xiao Zhao; Greg J. Anderson; Ying Zhao; Guangjun Nie

doi:10.1021/acsami.7b19258

Injectable Hexapeptide Hydrogel for Localized Chemotherapy Prevents Breast Cancer Recurrence

Yingqiu Qi, Huan Min, Ayeesha Mujeeb, Yinlong Zhang, Xuexiang Han, Xiao Zhao, Greg J. Anderson, Ying Zhao, Guangjun Nie

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Although postsurgical chemotherapy is frequently used for the treatment of breast cancer, tumor recurrence is still a frequent event. Enhancing the efficacy of chemotherapy via localized drug delivery may help to prevent breast cancer recurrence. To achieve this goal, we designed a hydrogel nanocarrier that could be injected at the tumor site by coassembly of tailor-made hexapeptide and doxorubicin. Evidently, on the basis of our findings, the sustained release of drug from the hydrogel led to a reduction in cancer recurrence, including the suppression of primary regrowth and distant metastasis. This localized chemotherapy strategy did not show any obvious side effects in vivo and represents a promising adjuvant therapeutic strategy for breast cancer recurrence.

Original language	English (US)
Pages (from-to)	6972-6981
Number of pages	10
Journal	ACS Applied Materials and Interfaces
Volume	10
Issue number	8
DOIs	https://doi.org/10.1021/acsami.7b19258
State	Published - Feb 28 2018

Keywords

cancer recurrence
hydrogel
injectable
localized chemotherapy
peptide self-assembly

ASJC Scopus subject areas

Materials Science(all)

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10.1021/acsami.7b19258

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Injectable Hexapeptide Hydrogel for Localized Chemotherapy Prevents Breast Cancer Recurrence. / Qi, Yingqiu; Min, Huan; Mujeeb, Ayeesha; Zhang, Yinlong; Han, Xuexiang; Zhao, Xiao; Anderson, Greg J.; Zhao, Ying; Nie, Guangjun.

In: ACS Applied Materials and Interfaces, Vol. 10, No. 8, 28.02.2018, p. 6972-6981.

Research output: Contribution to journal › Article › peer-review

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title = "Injectable Hexapeptide Hydrogel for Localized Chemotherapy Prevents Breast Cancer Recurrence",

abstract = "Although postsurgical chemotherapy is frequently used for the treatment of breast cancer, tumor recurrence is still a frequent event. Enhancing the efficacy of chemotherapy via localized drug delivery may help to prevent breast cancer recurrence. To achieve this goal, we designed a hydrogel nanocarrier that could be injected at the tumor site by coassembly of tailor-made hexapeptide and doxorubicin. Evidently, on the basis of our findings, the sustained release of drug from the hydrogel led to a reduction in cancer recurrence, including the suppression of primary regrowth and distant metastasis. This localized chemotherapy strategy did not show any obvious side effects in vivo and represents a promising adjuvant therapeutic strategy for breast cancer recurrence.",

keywords = "cancer recurrence, hydrogel, injectable, localized chemotherapy, peptide self-assembly",

author = "Yingqiu Qi and Huan Min and Ayeesha Mujeeb and Yinlong Zhang and Xuexiang Han and Xiao Zhao and Anderson, {Greg J.} and Ying Zhao and Guangjun Nie",

note = "Funding Information: This work was supported by the Excellent Young Scientists Fund (31722021), the National Natural Science Foundation of China (21373067 and 51673051), Beijing Nova Program (Z171100001117010), Beijing Natural Science Foundation (7172164), Youth Innovation Promotion Association CAS (2017056), the National Distinguished Young Scientists program (31325010), the Innovation Research Group of the National Natural Science Foundation (11621505), the Key Research Project of Frontier Science of the Chinese Academy of Sciences (QYZDJ-SSW-SLH022), and Beijing Municipal Science & Technology Commission (Z161100000116035). Publisher Copyright: {\textcopyright} 2018 American Chemical Society. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

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AU - Zhao, Ying

AU - Nie, Guangjun

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N2 - Although postsurgical chemotherapy is frequently used for the treatment of breast cancer, tumor recurrence is still a frequent event. Enhancing the efficacy of chemotherapy via localized drug delivery may help to prevent breast cancer recurrence. To achieve this goal, we designed a hydrogel nanocarrier that could be injected at the tumor site by coassembly of tailor-made hexapeptide and doxorubicin. Evidently, on the basis of our findings, the sustained release of drug from the hydrogel led to a reduction in cancer recurrence, including the suppression of primary regrowth and distant metastasis. This localized chemotherapy strategy did not show any obvious side effects in vivo and represents a promising adjuvant therapeutic strategy for breast cancer recurrence.

AB - Although postsurgical chemotherapy is frequently used for the treatment of breast cancer, tumor recurrence is still a frequent event. Enhancing the efficacy of chemotherapy via localized drug delivery may help to prevent breast cancer recurrence. To achieve this goal, we designed a hydrogel nanocarrier that could be injected at the tumor site by coassembly of tailor-made hexapeptide and doxorubicin. Evidently, on the basis of our findings, the sustained release of drug from the hydrogel led to a reduction in cancer recurrence, including the suppression of primary regrowth and distant metastasis. This localized chemotherapy strategy did not show any obvious side effects in vivo and represents a promising adjuvant therapeutic strategy for breast cancer recurrence.

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Injectable Hexapeptide Hydrogel for Localized Chemotherapy Prevents Breast Cancer Recurrence

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