Injectable Hexapeptide Hydrogel for Localized Chemotherapy Prevents Breast Cancer Recurrence

Yingqiu Qi, Huan Min, Ayeesha Mujeeb, Yinlong Zhang, Xuexiang Han, Xiao Zhao, Greg J. Anderson, Ying Zhao, Guangjun Nie

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Although postsurgical chemotherapy is frequently used for the treatment of breast cancer, tumor recurrence is still a frequent event. Enhancing the efficacy of chemotherapy via localized drug delivery may help to prevent breast cancer recurrence. To achieve this goal, we designed a hydrogel nanocarrier that could be injected at the tumor site by coassembly of tailor-made hexapeptide and doxorubicin. Evidently, on the basis of our findings, the sustained release of drug from the hydrogel led to a reduction in cancer recurrence, including the suppression of primary regrowth and distant metastasis. This localized chemotherapy strategy did not show any obvious side effects in vivo and represents a promising adjuvant therapeutic strategy for breast cancer recurrence.

Original languageEnglish (US)
Pages (from-to)6972-6981
Number of pages10
JournalACS Applied Materials and Interfaces
Volume10
Issue number8
DOIs
StatePublished - Feb 28 2018

Keywords

  • cancer recurrence
  • hydrogel
  • injectable
  • localized chemotherapy
  • peptide self-assembly

ASJC Scopus subject areas

  • Materials Science(all)

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