Inhibitory effect of galanin on basal and pentagastrin-stimulated gastric acid secretion in rats

R. V. Yagci; N. Alptekin; W. J. Rossowski; A. Brown; D. H. Coy; A. Ertan

doi:10.3109/00365529008999225

Inhibitory effect of galanin on basal and pentagastrin-stimulated gastric acid secretion in rats

R. V. Yagci, N. Alptekin, W. J. Rossowski, A. Brown, D. H. Coy, A. Ertan

Houston Methodist

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The dose-dependent effects of galanin on basal and pentagastrin-stimulated gastric acid secretion in pentobarbital-anesthetized rats were examined. Intravenous infusion of galanin at doses of 0.31, 0.62, 1.25, 1.87, 3.11, and 6.22 nmol/kg^-1/h^-1 into pentagastrin-stimulated rats produced a diminution in gastric acid secretion which was maximal (54.7%) at the level of the 1.87 nmol/kg^-1/h^-1 dose. Furthermore, the effect was biphasic, since both lower and higher doses of peptide were less effective. At the optimum concentration of 1.87 nmol/kg^-1/h^-1 galanin also inhibited basal gastric acid secretion. We conclude that endogenous galanin might be involved in the physiologic regulation of gastric acid secretion.

Original language	English (US)
Pages (from-to)	853-858
Number of pages	6
Journal	Scandinavian Journal of Gastroenterology
Volume	25
Issue number	8
DOIs	https://doi.org/10.3109/00365529008999225
State	Published - 1990

Keywords

Basal
Galanin inhibition
Gastric acid secretion Pentagastrin-stimulated

ASJC Scopus subject areas

Gastroenterology

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10.3109/00365529008999225

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title = "Inhibitory effect of galanin on basal and pentagastrin-stimulated gastric acid secretion in rats",

abstract = "The dose-dependent effects of galanin on basal and pentagastrin-stimulated gastric acid secretion in pentobarbital-anesthetized rats were examined. Intravenous infusion of galanin at doses of 0.31, 0.62, 1.25, 1.87, 3.11, and 6.22 nmol/kg-1/h-1 into pentagastrin-stimulated rats produced a diminution in gastric acid secretion which was maximal (54.7\%) at the level of the 1.87 nmol/kg-1/h-1 dose. Furthermore, the effect was biphasic, since both lower and higher doses of peptide were less effective. At the optimum concentration of 1.87 nmol/kg-1/h-1 galanin also inhibited basal gastric acid secretion. We conclude that endogenous galanin might be involved in the physiologic regulation of gastric acid secretion.",

keywords = "Basal, Galanin inhibition, Gastric acid secretion Pentagastrin-stimulated",

author = "Yagci, \{R. V.\} and N. Alptekin and Rossowski, \{W. J.\} and A. Brown and Coy, \{D. H.\} and A. Ertan",

note = "Funding Information: We thank Mrs. Etchie Yauger for her expert technical assistance, Janet C. Rice, Ph.D., for statistical analysis, and Gillian F. Brown, Ph.D., for editorial assistance. This work was supported by NIH grant DK-18370 (to D. H. Coy). Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1990",

doi = "10.3109/00365529008999225",

language = "English (US)",

volume = "25",

pages = "853--858",

journal = "Scandinavian Journal of Gastroenterology",

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T1 - Inhibitory effect of galanin on basal and pentagastrin-stimulated gastric acid secretion in rats

AU - Yagci, R. V.

AU - Alptekin, N.

AU - Rossowski, W. J.

AU - Brown, A.

AU - Coy, D. H.

AU - Ertan, A.

N1 - Funding Information: We thank Mrs. Etchie Yauger for her expert technical assistance, Janet C. Rice, Ph.D., for statistical analysis, and Gillian F. Brown, Ph.D., for editorial assistance. This work was supported by NIH grant DK-18370 (to D. H. Coy). Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1990

Y1 - 1990

N2 - The dose-dependent effects of galanin on basal and pentagastrin-stimulated gastric acid secretion in pentobarbital-anesthetized rats were examined. Intravenous infusion of galanin at doses of 0.31, 0.62, 1.25, 1.87, 3.11, and 6.22 nmol/kg-1/h-1 into pentagastrin-stimulated rats produced a diminution in gastric acid secretion which was maximal (54.7%) at the level of the 1.87 nmol/kg-1/h-1 dose. Furthermore, the effect was biphasic, since both lower and higher doses of peptide were less effective. At the optimum concentration of 1.87 nmol/kg-1/h-1 galanin also inhibited basal gastric acid secretion. We conclude that endogenous galanin might be involved in the physiologic regulation of gastric acid secretion.

AB - The dose-dependent effects of galanin on basal and pentagastrin-stimulated gastric acid secretion in pentobarbital-anesthetized rats were examined. Intravenous infusion of galanin at doses of 0.31, 0.62, 1.25, 1.87, 3.11, and 6.22 nmol/kg-1/h-1 into pentagastrin-stimulated rats produced a diminution in gastric acid secretion which was maximal (54.7%) at the level of the 1.87 nmol/kg-1/h-1 dose. Furthermore, the effect was biphasic, since both lower and higher doses of peptide were less effective. At the optimum concentration of 1.87 nmol/kg-1/h-1 galanin also inhibited basal gastric acid secretion. We conclude that endogenous galanin might be involved in the physiologic regulation of gastric acid secretion.

KW - Basal

KW - Galanin inhibition

KW - Gastric acid secretion Pentagastrin-stimulated

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SN - 0036-5521

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JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

IS - 8

ER -

Inhibitory effect of galanin on basal and pentagastrin-stimulated gastric acid secretion in rats

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