Inhibitory effect of galanin on basal and pentagastrin-stimulated gastric acid secretion in rats

R. V. Yagci, N. Alptekin, W. J. Rossowski, A. Brown, D. H. Coy, A. Ertan

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The dose-dependent effects of galanin on basal and pentagastrin-stimulated gastric acid secretion in pentobarbital-anesthetized rats were examined. Intravenous infusion of galanin at doses of 0.31, 0.62, 1.25, 1.87, 3.11, and 6.22 nmol/kg-1/h-1 into pentagastrin-stimulated rats produced a diminution in gastric acid secretion which was maximal (54.7%) at the level of the 1.87 nmol/kg-1/h-1 dose. Furthermore, the effect was biphasic, since both lower and higher doses of peptide were less effective. At the optimum concentration of 1.87 nmol/kg-1/h-1 galanin also inhibited basal gastric acid secretion. We conclude that endogenous galanin might be involved in the physiologic regulation of gastric acid secretion.

Original languageEnglish (US)
Pages (from-to)853-858
Number of pages6
JournalScandinavian Journal of Gastroenterology
Volume25
Issue number8
DOIs
StatePublished - 1990

Keywords

  • Basal
  • Galanin inhibition
  • Gastric acid secretion Pentagastrin-stimulated

ASJC Scopus subject areas

  • Gastroenterology

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