Inhibitory control in obesity and binge eating disorder: A systematic review and meta-analysis of neurocognitive and neuroimaging studies

Luca Lavagnino, Danilo Arnone, Bo Cao, Jair C. Soares, Sudhakar Selvaraj

Research output: Contribution to journalReview article

102 Scopus citations

Abstract

The ability to exercise appropriate inhibitory control is critical in the regulation of body weight, but the exact mechanisms are not known. In this systematic review, we identified 37 studies that used specific neuropsychological tasks relevant to inhibitory control performance in obese participants with and without binge eating disorder (BED). We performed a meta-analysis of the studies that used the stop signal task (N = 8). We further examined studies on the delay discounting task, the go/no-go task and the Stroop task in a narrative review. We found that inhibitory control is significantly impaired in obese adults and children compared to individuals with body weight within a healthy range (Standardized Mean Difference (SMD): 0.30; CI = 0.00, 0.59, p = 0.007). The presence of BED in obese individuals did not impact on task performance (SMD: 0.05; CI: −0.22, 0.32, p = 0.419). Neuroimaging studies in obesity suggest that lower prefrontal cortex activity affects inhibitory control and BMI. In summary, impairment in inhibitory control is a critical feature associated with obesity and a potential target for clinical interventions.

Original languageEnglish (US)
Pages (from-to)714-726
Number of pages13
JournalNeuroscience and Biobehavioral Reviews
Volume68
DOIs
StatePublished - Sep 1 2016

Keywords

  • Binge eating
  • Go/nogo
  • Inhibitory control
  • Obesity
  • Prefrontal cortex
  • Stop signal

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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