Inhibition of M13 phage synthesis by rifampicin in some rifampicin-resistant Escherichia coli mutants

Sankar Mitra

doi:10.1016/0042-6822(72)90394-7

Inhibition of M13 phage synthesis by rifampicin in some rifampicin-resistant Escherichia coli mutants

Sankar Mitra

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

In certain Escherichia coli strains that have altered RNA polymerases and are resistant to low levels of rifampicin, M13 phage synthesis is almost totally inhibited by the drug at concentrations that do not affect significantly the bacterial growth rate. Rifampicin does not prevent release of progeny phage particles from the cells, and its effect is reversible. The inhibition of phage synthesis is due to inhibition of phage mRNA synthesis by the drug.

Original language	English (US)
Pages (from-to)	422-430
Number of pages	9
Journal	Virology
Volume	50
Issue number	2
DOIs	https://doi.org/10.1016/0042-6822(72)90394-7
State	Published - Jan 1 1972

ASJC Scopus subject areas

Virology

Access to Document

10.1016/0042-6822(72)90394-7

Cite this

@article{3d21ba0a575c4a629d542692fa599f9d,

title = "Inhibition of M13 phage synthesis by rifampicin in some rifampicin-resistant Escherichia coli mutants",

abstract = "In certain Escherichia coli strains that have altered RNA polymerases and are resistant to low levels of rifampicin, M13 phage synthesis is almost totally inhibited by the drug at concentrations that do not affect significantly the bacterial growth rate. Rifampicin does not prevent release of progeny phage particles from the cells, and its effect is reversible. The inhibition of phage synthesis is due to inhibition of phage mRNA synthesis by the drug.",

author = "Sankar Mitra",

year = "1972",

month = jan,

day = "1",

doi = "10.1016/0042-6822(72)90394-7",

language = "English (US)",

volume = "50",

pages = "422--430",

journal = "Virology",

issn = "0042-6822",

publisher = "Academic Press",

number = "2",

}

TY - JOUR

T1 - Inhibition of M13 phage synthesis by rifampicin in some rifampicin-resistant Escherichia coli mutants

AU - Mitra, Sankar

PY - 1972/1/1

Y1 - 1972/1/1

N2 - In certain Escherichia coli strains that have altered RNA polymerases and are resistant to low levels of rifampicin, M13 phage synthesis is almost totally inhibited by the drug at concentrations that do not affect significantly the bacterial growth rate. Rifampicin does not prevent release of progeny phage particles from the cells, and its effect is reversible. The inhibition of phage synthesis is due to inhibition of phage mRNA synthesis by the drug.

AB - In certain Escherichia coli strains that have altered RNA polymerases and are resistant to low levels of rifampicin, M13 phage synthesis is almost totally inhibited by the drug at concentrations that do not affect significantly the bacterial growth rate. Rifampicin does not prevent release of progeny phage particles from the cells, and its effect is reversible. The inhibition of phage synthesis is due to inhibition of phage mRNA synthesis by the drug.

UR - http://www.scopus.com/inward/record.url?scp=0015427281&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015427281&partnerID=8YFLogxK

U2 - 10.1016/0042-6822(72)90394-7

DO - 10.1016/0042-6822(72)90394-7

M3 - Article

C2 - 4564525

AN - SCOPUS:0015427281

VL - 50

SP - 422

EP - 430

JO - Virology

JF - Virology

SN - 0042-6822

IS - 2

ER -

Inhibition of M13 phage synthesis by rifampicin in some rifampicin-resistant Escherichia coli mutants

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this