Inhibition of M13 phage synthesis by rifampicin in some rifampicin-resistant Escherichia coli mutants

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Abstract

In certain Escherichia coli strains that have altered RNA polymerases and are resistant to low levels of rifampicin, M13 phage synthesis is almost totally inhibited by the drug at concentrations that do not affect significantly the bacterial growth rate. Rifampicin does not prevent release of progeny phage particles from the cells, and its effect is reversible. The inhibition of phage synthesis is due to inhibition of phage mRNA synthesis by the drug.

Original languageEnglish (US)
Pages (from-to)422-430
Number of pages9
JournalVirology
Volume50
Issue number2
DOIs
StatePublished - Jan 1 1972

ASJC Scopus subject areas

  • Virology

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