Inhibition of human lymphocyte cyclic nucleotide phosphodiesterases by the chlorinated adenosine analog DTA-35

M. Y. Hurwitz; R. L. Hurwitz; R. D. Edstrom

doi:10.3109/14756368709020124

Inhibition of human lymphocyte cyclic nucleotide phosphodiesterases by the chlorinated adenosine analog DTA-35

M. Y. Hurwitz, R. L. Hurwitz, R. D. Edstrom

Houston Methodist

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Human (E†T-lymphocytes have multiple cyclic nucleotide phosphodiesterase activities, some of which are markedly inhibited by the chlorinated adenosine derivative 9-(3′5′dichloro-2′3′5′trideoxy-βD-rtreo-pentofuranosyl)adenine (DTA-35).

Original language	English (US)
Pages (from-to)	267-274
Number of pages	8
Journal	Journal of Enzyme Inhibition and Medicinal Chemistry
Volume	1
Issue number	4
DOIs	https://doi.org/10.3109/14756368709020124
State	Published - 1987

Keywords

Chlorinated adenosine analog
Cyclic nucleotides
Phosphodiesterase

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.3109/14756368709020124

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@article{545787ebc3f14166a0028d154f111322,

title = "Inhibition of human lymphocyte cyclic nucleotide phosphodiesterases by the chlorinated adenosine analog DTA-35",

abstract = "Human (E†T-lymphocytes have multiple cyclic nucleotide phosphodiesterase activities, some of which are markedly inhibited by the chlorinated adenosine derivative 9-(3′5′dichloro-2′3′5′trideoxy-βD-rtreo-pentofuranosyl)adenine (DTA-35).",

keywords = "Chlorinated adenosine analog, Cyclic nucleotides, Phosphodiesterase",

author = "Hurwitz, \{M. Y.\} and Hurwitz, \{R. L.\} and Edstrom, \{R. D.\}",

note = "Funding Information: This work was supported by grants from the University of Minnesota Graduate School and the Minnesota Leukemia Task Force. We would like to thank Harry P.C. Hogenkamp for the gift of the DTA-35 and Marilyn H. Meinke for helpful discussions while preparing the manuscript. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1987",

doi = "10.3109/14756368709020124",

language = "English (US)",

volume = "1",

pages = "267--274",

journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",

issn = "1475-6366",

publisher = "Taylor and Francis Ltd.",

number = "4",

}

TY - JOUR

T1 - Inhibition of human lymphocyte cyclic nucleotide phosphodiesterases by the chlorinated adenosine analog DTA-35

AU - Hurwitz, M. Y.

AU - Hurwitz, R. L.

AU - Edstrom, R. D.

N1 - Funding Information: This work was supported by grants from the University of Minnesota Graduate School and the Minnesota Leukemia Task Force. We would like to thank Harry P.C. Hogenkamp for the gift of the DTA-35 and Marilyn H. Meinke for helpful discussions while preparing the manuscript. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1987

Y1 - 1987

N2 - Human (E†T-lymphocytes have multiple cyclic nucleotide phosphodiesterase activities, some of which are markedly inhibited by the chlorinated adenosine derivative 9-(3′5′dichloro-2′3′5′trideoxy-βD-rtreo-pentofuranosyl)adenine (DTA-35).

AB - Human (E†T-lymphocytes have multiple cyclic nucleotide phosphodiesterase activities, some of which are markedly inhibited by the chlorinated adenosine derivative 9-(3′5′dichloro-2′3′5′trideoxy-βD-rtreo-pentofuranosyl)adenine (DTA-35).

KW - Chlorinated adenosine analog

KW - Cyclic nucleotides

KW - Phosphodiesterase

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UR - https://www.scopus.com/inward/citedby.url?scp=0023279603&partnerID=8YFLogxK

U2 - 10.3109/14756368709020124

DO - 10.3109/14756368709020124

M3 - Article

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AN - SCOPUS:0023279603

SN - 1475-6366

VL - 1

SP - 267

EP - 274

JO - Journal of Enzyme Inhibition and Medicinal Chemistry

JF - Journal of Enzyme Inhibition and Medicinal Chemistry

IS - 4

ER -

Inhibition of human lymphocyte cyclic nucleotide phosphodiesterases by the chlorinated adenosine analog DTA-35

Abstract

Keywords

ASJC Scopus subject areas

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