Inhibition of human lymphocyte cyclic nucleotide phosphodiesterases by the chlorinated adenosine analog DTA-35

M. Y. Hurwitz, R. L. Hurwitz, R. D. Edstrom

Research output: Contribution to journalArticlepeer-review

Abstract

Human (E†T-lymphocytes have multiple cyclic nucleotide phosphodiesterase activities, some of which are markedly inhibited by the chlorinated adenosine derivative 9-(3′5′dichloro-2′3′5′trideoxy-βD-rtreo-pentofuranosyl)adenine (DTA-35).

Original languageEnglish (US)
Pages (from-to)267-274
Number of pages8
JournalJournal of Enzyme Inhibition and Medicinal Chemistry
Volume1
Issue number4
DOIs
StatePublished - 1987

Keywords

  • Chlorinated adenosine analog
  • Cyclic nucleotides
  • Phosphodiesterase

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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