Inhibition of cyclooxygenase-2: An approach to preventing cancer of the upper aerodigestive tract

Andrew J. Dannenberg; Nasser K. Altorki; Jay O. Boyle; Derrick T. Lin; Kotha Subbaramaiah

doi:10.1111/j.1749-6632.2001.tb02731.x

Inhibition of cyclooxygenase-2: An approach to preventing cancer of the upper aerodigestive tract

Andrew J. Dannenberg, Nasser K. Altorki, Jay O. Boyle, Derrick T. Lin, Kotha Subbaramaiah

Research Institute

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56 Scopus citations

Abstract

Multiple lines of evidence suggest that cyclooxygenase-2 (COX-2), an inducible form of COX, represents a potential pharmacologic target to prevent cancer. Key data suggesting a causal relationship between increased COX-2 activity and carcinogenesis and possible mechanisms of action of COX-2 in this context will be discussed. The possibility that COX-2 represents a pharmacological target for preventing upper aerodigestive cancers (head and neck, lung) will be emphasized. Importantly, clinical trials have been initiated to assess the chemopreventive properties of selective COX-2 inhibitors.

Original language	English (US)
Pages (from-to)	109-115
Number of pages	7
Journal	Annals of the New York Academy of Sciences
Volume	952
DOIs	https://doi.org/10.1111/j.1749-6632.2001.tb02731.x
State	Published - 2001

Keywords

Aerodigestive
Chemoprevention
Cyclooxygenase-2
Nonsteroidal anti-inflammatory drugs
Prostaglandins

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1111/j.1749-6632.2001.tb02731.x

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title = "Inhibition of cyclooxygenase-2: An approach to preventing cancer of the upper aerodigestive tract",

abstract = "Multiple lines of evidence suggest that cyclooxygenase-2 (COX-2), an inducible form of COX, represents a potential pharmacologic target to prevent cancer. Key data suggesting a causal relationship between increased COX-2 activity and carcinogenesis and possible mechanisms of action of COX-2 in this context will be discussed. The possibility that COX-2 represents a pharmacological target for preventing upper aerodigestive cancers (head and neck, lung) will be emphasized. Importantly, clinical trials have been initiated to assess the chemopreventive properties of selective COX-2 inhibitors.",

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T1 - Inhibition of cyclooxygenase-2

T2 - An approach to preventing cancer of the upper aerodigestive tract

AU - Dannenberg, Andrew J.

AU - Altorki, Nasser K.

AU - Boyle, Jay O.

AU - Lin, Derrick T.

AU - Subbaramaiah, Kotha

PY - 2001

Y1 - 2001

N2 - Multiple lines of evidence suggest that cyclooxygenase-2 (COX-2), an inducible form of COX, represents a potential pharmacologic target to prevent cancer. Key data suggesting a causal relationship between increased COX-2 activity and carcinogenesis and possible mechanisms of action of COX-2 in this context will be discussed. The possibility that COX-2 represents a pharmacological target for preventing upper aerodigestive cancers (head and neck, lung) will be emphasized. Importantly, clinical trials have been initiated to assess the chemopreventive properties of selective COX-2 inhibitors.

AB - Multiple lines of evidence suggest that cyclooxygenase-2 (COX-2), an inducible form of COX, represents a potential pharmacologic target to prevent cancer. Key data suggesting a causal relationship between increased COX-2 activity and carcinogenesis and possible mechanisms of action of COX-2 in this context will be discussed. The possibility that COX-2 represents a pharmacological target for preventing upper aerodigestive cancers (head and neck, lung) will be emphasized. Importantly, clinical trials have been initiated to assess the chemopreventive properties of selective COX-2 inhibitors.

KW - Aerodigestive

KW - Chemoprevention

KW - Cyclooxygenase-2

KW - Nonsteroidal anti-inflammatory drugs

KW - Prostaglandins

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AN - SCOPUS:0035683884

SN - 0077-8923

VL - 952

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JO - Annals of the New York Academy of Sciences

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Inhibition of cyclooxygenase-2: An approach to preventing cancer of the upper aerodigestive tract

Abstract

Keywords

ASJC Scopus subject areas

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