Inhibition of cyclooxygenase-2: An approach to preventing cancer of the upper aerodigestive tract

Andrew J. Dannenberg, Nasser K. Altorki, Jay O. Boyle, Derrick T. Lin, Kotha Subbaramaiah

    Research output: Contribution to journalArticlepeer-review

    56 Scopus citations

    Abstract

    Multiple lines of evidence suggest that cyclooxygenase-2 (COX-2), an inducible form of COX, represents a potential pharmacologic target to prevent cancer. Key data suggesting a causal relationship between increased COX-2 activity and carcinogenesis and possible mechanisms of action of COX-2 in this context will be discussed. The possibility that COX-2 represents a pharmacological target for preventing upper aerodigestive cancers (head and neck, lung) will be emphasized. Importantly, clinical trials have been initiated to assess the chemopreventive properties of selective COX-2 inhibitors.

    Original languageEnglish (US)
    Pages (from-to)109-115
    Number of pages7
    JournalAnnals of the New York Academy of Sciences
    Volume952
    DOIs
    StatePublished - 2001

    Keywords

    • Aerodigestive
    • Chemoprevention
    • Cyclooxygenase-2
    • Nonsteroidal anti-inflammatory drugs
    • Prostaglandins

    ASJC Scopus subject areas

    • General Biochemistry, Genetics and Molecular Biology

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