Inhibition of cyclooxygenase-2: An approach to preventing cancer of the upper aerodigestive tract

Andrew J. Dannenberg, Nasser K. Altorki, Jay O. Boyle, Derrick T. Lin, Kotha Subbaramaiah

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

Multiple lines of evidence suggest that cyclooxygenase-2 (COX-2), an inducible form of COX, represents a potential pharmacologic target to prevent cancer. Key data suggesting a causal relationship between increased COX-2 activity and carcinogenesis and possible mechanisms of action of COX-2 in this context will be discussed. The possibility that COX-2 represents a pharmacological target for preventing upper aerodigestive cancers (head and neck, lung) will be emphasized. Importantly, clinical trials have been initiated to assess the chemopreventive properties of selective COX-2 inhibitors.

Original languageEnglish (US)
Pages (from-to)109-115
Number of pages7
JournalAnnals of the New York Academy of Sciences
Volume952
DOIs
StatePublished - 2001

Keywords

  • Aerodigestive
  • Chemoprevention
  • Cyclooxygenase-2
  • Nonsteroidal anti-inflammatory drugs
  • Prostaglandins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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