Inhibition of 7,12-dimethylbenzanthracene-induced rat mammary tumor growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin

M. Holcomb, S. Safe

Research output: Contribution to journalArticle

88 Scopus citations

Abstract

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds inhibit diverse estrogen-induced responses in the rodent uterus and human breast cancer cells. The effects of a single non-toxic dose of TCDD (10 μg/kg) on the development of mammary tumors was investigated in female Sprague-Dawley rats treated with an oral dose of 7,12-dimethylbenzanthracene (DMBA) (20 mg). In rats which developed mammary tumors, subsequent treatment with corn oil (vehicle) resulted in a 3.9-fold increase in mammary tumor volume after 21 days. In contrast, a second group of rats with mammary tumors were treated with a non-toxic dose of TCDD (10 μg/kg) and after 21 days, the mean tumor volumes decreased from 89.7 ± 53 mm3 to 24.9 ± 28.5 mm3. Moreover, these results demonstrate the antitumorigenic activity of TCDD in female Sprague-Dawley rats.

Original languageEnglish (US)
Pages (from-to)43-47
Number of pages5
JournalCancer Letters
Volume82
Issue number1
DOIs
StatePublished - Jul 15 1994

Keywords

  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin
  • Inhibition
  • Rat mammary tumors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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