Abstract
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds inhibit diverse estrogen-induced responses in the rodent uterus and human breast cancer cells. The effects of a single non-toxic dose of TCDD (10 μg/kg) on the development of mammary tumors was investigated in female Sprague-Dawley rats treated with an oral dose of 7,12-dimethylbenzanthracene (DMBA) (20 mg). In rats which developed mammary tumors, subsequent treatment with corn oil (vehicle) resulted in a 3.9-fold increase in mammary tumor volume after 21 days. In contrast, a second group of rats with mammary tumors were treated with a non-toxic dose of TCDD (10 μg/kg) and after 21 days, the mean tumor volumes decreased from 89.7 ± 53 mm3 to 24.9 ± 28.5 mm3. Moreover, these results demonstrate the antitumorigenic activity of TCDD in female Sprague-Dawley rats.
Original language | English (US) |
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Pages (from-to) | 43-47 |
Number of pages | 5 |
Journal | Cancer Letters |
Volume | 82 |
Issue number | 1 |
DOIs | |
State | Published - Jul 15 1994 |
Keywords
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin
- Inhibition
- Rat mammary tumors
ASJC Scopus subject areas
- Oncology
- Cancer Research