Inhibition of 3,3',4,4',5-pentachlorobiphenyl-induced chicken embryotoxicity by 2,2',4,4',5,5'-hexachlorobiphenyl

Feng Zhao, Kittane Mayura, Nathan Kocurek, John F. Edwards, Leon F. Kubena, Stephen H. Safe, Timothy D. Phillips

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


3,3',4,4',5-Pentachlorobiphenyl (pentaCB) caused a dose dependent induction of chicken embryolethality, malformations, edema, and liver lesions at doses ranging from 0.5 to 12.0 μg/kg. In contrast, no embryotoxicity was observed after treatment with 10, 25, or 50 mg/kg 2,2',4,4',5,5'-hexaCB. In eggs cotreated with 2.0 μg/kg, 3,3',4,4',5-pentaCB plus 10, 25, or 50 mg/kg 2,2',4,4',5,5'-hexaCB, there was significant protection from 3,3',4,4',5-pentaCB-induced embryo malformations, edema, and liver lesions, whereas no inhibition of embryolethality was observed. These results further extend the response-specific nonadditive interactions of binary mixtures of polychlorinated biphenyls (PCBs) and should be considered in the development of approaches for hazard assessment of PCB mixtures and related compounds.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalFundamental and Applied Toxicology
Issue number1
StatePublished - Jan 1997

ASJC Scopus subject areas

  • Toxicology


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