Inhibition of 3,3',4,4',5-pentachlorobiphenyl-induced chicken embryotoxicity by 2,2',4,4',5,5'-hexachlorobiphenyl

Feng Zhao, Kittane Mayura, Nathan Kocurek, John F. Edwards, Leon F. Kubena, Stephen H. Safe, Timothy D. Phillips

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

3,3',4,4',5-Pentachlorobiphenyl (pentaCB) caused a dose dependent induction of chicken embryolethality, malformations, edema, and liver lesions at doses ranging from 0.5 to 12.0 μg/kg. In contrast, no embryotoxicity was observed after treatment with 10, 25, or 50 mg/kg 2,2',4,4',5,5'-hexaCB. In eggs cotreated with 2.0 μg/kg, 3,3',4,4',5-pentaCB plus 10, 25, or 50 mg/kg 2,2',4,4',5,5'-hexaCB, there was significant protection from 3,3',4,4',5-pentaCB-induced embryo malformations, edema, and liver lesions, whereas no inhibition of embryolethality was observed. These results further extend the response-specific nonadditive interactions of binary mixtures of polychlorinated biphenyls (PCBs) and should be considered in the development of approaches for hazard assessment of PCB mixtures and related compounds.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalFundamental and Applied Toxicology
Volume35
Issue number1
DOIs
StatePublished - Jan 1997
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology

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