TY - JOUR
T1 - Inhibition of 3,3',4,4',5-pentachlorobiphenyl-induced chicken embryotoxicity by 2,2',4,4',5,5'-hexachlorobiphenyl
AU - Zhao, Feng
AU - Mayura, Kittane
AU - Kocurek, Nathan
AU - Edwards, John F.
AU - Kubena, Leon F.
AU - Safe, Stephen H.
AU - Phillips, Timothy D.
N1 - Funding Information:
The National Institutes of Health (P42-ES04917) and the Texas Agricultural Experiment Station (H6215) are gratefully acknowledged. S.S. is a Sid Kyle Professor of Toxicology.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1997/1
Y1 - 1997/1
N2 - 3,3',4,4',5-Pentachlorobiphenyl (pentaCB) caused a dose dependent induction of chicken embryolethality, malformations, edema, and liver lesions at doses ranging from 0.5 to 12.0 μg/kg. In contrast, no embryotoxicity was observed after treatment with 10, 25, or 50 mg/kg 2,2',4,4',5,5'-hexaCB. In eggs cotreated with 2.0 μg/kg, 3,3',4,4',5-pentaCB plus 10, 25, or 50 mg/kg 2,2',4,4',5,5'-hexaCB, there was significant protection from 3,3',4,4',5-pentaCB-induced embryo malformations, edema, and liver lesions, whereas no inhibition of embryolethality was observed. These results further extend the response-specific nonadditive interactions of binary mixtures of polychlorinated biphenyls (PCBs) and should be considered in the development of approaches for hazard assessment of PCB mixtures and related compounds.
AB - 3,3',4,4',5-Pentachlorobiphenyl (pentaCB) caused a dose dependent induction of chicken embryolethality, malformations, edema, and liver lesions at doses ranging from 0.5 to 12.0 μg/kg. In contrast, no embryotoxicity was observed after treatment with 10, 25, or 50 mg/kg 2,2',4,4',5,5'-hexaCB. In eggs cotreated with 2.0 μg/kg, 3,3',4,4',5-pentaCB plus 10, 25, or 50 mg/kg 2,2',4,4',5,5'-hexaCB, there was significant protection from 3,3',4,4',5-pentaCB-induced embryo malformations, edema, and liver lesions, whereas no inhibition of embryolethality was observed. These results further extend the response-specific nonadditive interactions of binary mixtures of polychlorinated biphenyls (PCBs) and should be considered in the development of approaches for hazard assessment of PCB mixtures and related compounds.
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U2 - 10.1006/faat.1996.2251
DO - 10.1006/faat.1996.2251
M3 - Article
C2 - 9024668
AN - SCOPUS:85033537675
VL - 35
SP - 1
EP - 8
JO - Fundamental and Applied Toxicology
JF - Fundamental and Applied Toxicology
SN - 0272-0590
IS - 1
ER -