Inherited human caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II

Jin Wang, Lixin Zheng, Adrian Lobito, Francis Ka Ming Chan, Janet Dale, Michael Sneller, Xu Yao, Jennifer M. Puck, Stephen E. Straus, Michael J. Lenardo

Research output: Contribution to journalArticle

489 Scopus citations

Abstract

Caspases are cysteine proteases that mediate programmed cell death in phylogenetically diverse multicellular organisms. We report here two kindreds with autoimmune lymphoproliferative syndrome (ALPS) type II, characterized by abnormal lymphocyte and dendritic cell homeostasis and immune regulatory defects, that harbor independent missense mutations in Caspase 10. These encode amino acid substitutions that decrease caspase activity and interfere with death receptor-induced apoptosis, particularly that stimulated by Fas ligand and TRAIL. These results provide evidence that inherited nonlethal caspase abnormalities cause pleiotropic apoptosis defects underlying autoimmunity in ALPS type II.

Original languageEnglish (US)
Pages (from-to)47-58
Number of pages12
JournalCell
Volume98
Issue number1
DOIs
StatePublished - Jul 9 1999

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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