Inherited combined deficiency of factor V and factor VIII: Report of a case with normal factor VIII antigen and ristocetin‐induced platelet aggregation

P. L. Cimo; J. L. Moake; M. F. Gonzalez; E. A. Natelson; K. R. Fox

doi:10.1002/ajh.2830020408

Inherited combined deficiency of factor V and factor VIII: Report of a case with normal factor VIII antigen and ristocetin‐induced platelet aggregation

P. L. Cimo, J. L. Moake, M. F. Gonzalez, E. A. Natelson, K. R. Fox

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9 Scopus citations

Abstract

A patient with inherited combined deficiency of factor V and factor VIII is reported, who demonstrated normal levels of factor VIII antigen and plasma cofactor for ristocetin-induced platelet aggregation. The relationship of this condition to classical hemophilia and von Willebrand's disease is discussed. The data presented suggest that multiple loci on at least 2 chromosomes are necessary for the normal expression of factor VIII activity.

Original language	English (US)
Pages (from-to)	385-391
Number of pages	7
Journal	American Journal of Hematology
Volume	2
Issue number	4
DOIs	https://doi.org/10.1002/ajh.2830020408
State	Published - 1977

Keywords

blood coagulation disorders
factor V deficiency
hemophilia

ASJC Scopus subject areas

Hematology

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10.1002/ajh.2830020408

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abstract = "A patient with inherited combined deficiency of factor V and factor VIII is reported, who demonstrated normal levels of factor VIII antigen and plasma cofactor for ristocetin-induced platelet aggregation. The relationship of this condition to classical hemophilia and von Willebrand's disease is discussed. The data presented suggest that multiple loci on at least 2 chromosomes are necessary for the normal expression of factor VIII activity.",

keywords = "blood coagulation disorders, factor V deficiency, hemophilia",

author = "Cimo, {P. L.} and Moake, {J. L.} and Gonzalez, {M. F.} and Natelson, {E. A.} and Fox, {K. R.}",

year = "1977",

doi = "10.1002/ajh.2830020408",

language = "English (US)",

volume = "2",

pages = "385--391",

journal = "American Journal of Hematology",

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T2 - Report of a case with normal factor VIII antigen and ristocetin‐induced platelet aggregation

AU - Cimo, P. L.

AU - Moake, J. L.

AU - Gonzalez, M. F.

AU - Natelson, E. A.

AU - Fox, K. R.

PY - 1977

Y1 - 1977

N2 - A patient with inherited combined deficiency of factor V and factor VIII is reported, who demonstrated normal levels of factor VIII antigen and plasma cofactor for ristocetin-induced platelet aggregation. The relationship of this condition to classical hemophilia and von Willebrand's disease is discussed. The data presented suggest that multiple loci on at least 2 chromosomes are necessary for the normal expression of factor VIII activity.

AB - A patient with inherited combined deficiency of factor V and factor VIII is reported, who demonstrated normal levels of factor VIII antigen and plasma cofactor for ristocetin-induced platelet aggregation. The relationship of this condition to classical hemophilia and von Willebrand's disease is discussed. The data presented suggest that multiple loci on at least 2 chromosomes are necessary for the normal expression of factor VIII activity.

KW - blood coagulation disorders

KW - factor V deficiency

KW - hemophilia

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U2 - 10.1002/ajh.2830020408

DO - 10.1002/ajh.2830020408

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JF - American Journal of Hematology

IS - 4

ER -

Inherited combined deficiency of factor V and factor VIII: Report of a case with normal factor VIII antigen and ristocetin‐induced platelet aggregation

Abstract

Keywords

ASJC Scopus subject areas

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