Inhalable Microparticles Embedding Biocompatible Magnetic Iron-Doped Hydroxyapatite Nanoparticles

Eride Quarta, Michele Chiappi, Alessio Adamiano, Anna Tampieri, Weijie Wang, Teresa D. Tetley, Francesca Buttini, Fabio Sonvico, Daniele Catalucci, Paolo Colombo, Michele Iafisco, Lorenzo Degli Esposti

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Recently, there has been increasing interest in developing biocompatible inhalable nanoparticle formulations, as they have enormous potential for treating and diagnosing lung disease. In this respect, here, we have studied superparamagnetic iron-doped calcium phosphate (in the form of hydroxyapatite) nanoparticles (FeCaP NPs) which were previously proved to be excellent materials for magnetic resonance imaging, drug delivery and hyperthermia-related applications. We have established that FeCaP NPs are not cytotoxic towards human lung alveolar epithelial type 1 (AT1) cells even at high doses, thus proving their safety for inhalation administration. Then, D-mannitol spray-dried microparticles embedding FeCaP NPs have been formulated, obtaining respirable dry powders. These microparticles were designed to achieve the best aerodynamic particle size distribution which is a critical condition for successful inhalation and deposition. The nanoparticle-in-microparticle approach resulted in the protection of FeCaP NPs, allowing their release upon microparticle dissolution, with dimensions and surface charge close to the original values. This work demonstrates the use of spray drying to provide an inhalable dry powder platform for the lung delivery of safe FeCaP NPs for magnetically driven applications.

Original languageEnglish (US)
Article number189
JournalJournal of Functional Biomaterials
Issue number4
StatePublished - Mar 28 2023


  • Trojan microparticles
  • hydroxyapatite
  • inhalable dry powder
  • microparticles embedding nanoparticles
  • nanomedicine
  • pulmonary disease
  • superparamagnetic nanoparticles

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering


Dive into the research topics of 'Inhalable Microparticles Embedding Biocompatible Magnetic Iron-Doped Hydroxyapatite Nanoparticles'. Together they form a unique fingerprint.

Cite this