Influenza B viruses with mutation in the neuraminidase active site, North Carolina, USA, 2010-11

Katrina Sleeman; Tiffany G. Sheu; Zack Moore; Susan Kilpatrick; Shikha Garg; Alicia M. Fry; Larisa V. Gubareva

doi:10.3201/eid1711.110787

Influenza B viruses with mutation in the neuraminidase active site, North Carolina, USA, 2010-11

Katrina Sleeman, Tiffany G. Sheu, Zack Moore, Susan Kilpatrick, Shikha Garg, Alicia M. Fry, Larisa V. Gubareva

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Oseltamivir is 1 of 2 antiviral medications available for the treatment of influenza B virus infections. We describe and characterize a cluster of influenza B viruses circulating in North Carolina with a mutation in the neuraminidase active site that may reduce susceptibility to oseltamivir and the investigational drug peramivir but not to zanamivir.

Original language	English (US)
Pages (from-to)	2043-2046
Number of pages	4
Journal	Emerging Infectious Diseases
Volume	17
Issue number	11
DOIs	https://doi.org/10.3201/eid1711.110787
State	Published - Nov 2011

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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10.3201/eid1711.110787

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abstract = "Oseltamivir is 1 of 2 antiviral medications available for the treatment of influenza B virus infections. We describe and characterize a cluster of influenza B viruses circulating in North Carolina with a mutation in the neuraminidase active site that may reduce susceptibility to oseltamivir and the investigational drug peramivir but not to zanamivir.",

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T1 - Influenza B viruses with mutation in the neuraminidase active site, North Carolina, USA, 2010-11

AU - Sleeman, Katrina

AU - Sheu, Tiffany G.

AU - Moore, Zack

AU - Kilpatrick, Susan

AU - Garg, Shikha

AU - Fry, Alicia M.

AU - Gubareva, Larisa V.

PY - 2011/11

Y1 - 2011/11

N2 - Oseltamivir is 1 of 2 antiviral medications available for the treatment of influenza B virus infections. We describe and characterize a cluster of influenza B viruses circulating in North Carolina with a mutation in the neuraminidase active site that may reduce susceptibility to oseltamivir and the investigational drug peramivir but not to zanamivir.

AB - Oseltamivir is 1 of 2 antiviral medications available for the treatment of influenza B virus infections. We describe and characterize a cluster of influenza B viruses circulating in North Carolina with a mutation in the neuraminidase active site that may reduce susceptibility to oseltamivir and the investigational drug peramivir but not to zanamivir.

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M3 - Article

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Influenza B viruses with mutation in the neuraminidase active site, North Carolina, USA, 2010-11

Abstract

ASJC Scopus subject areas

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