Influence of liver-X-receptor on tissue cholesterol, coenzyme Q and dolichol content

Magnus Bentinger, Michael Tekle, Gustav Dallner, Kerstin Brismar, Jan-Ake Gustafsson, Knut R. Steffensen, Sergiu Bogdan Catrina

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The organ content of the mevalonate pathway lipids was investigated in liver-X-receptor (LXR) α, β and double knock-out mice. An extensive or moderate increase of total cholesterol in the double KO mice was found in all organs elicited by the increase of the esterified form. In LXRα and double KO mice, coenzyme Q (CoQ) was decreased in liver and increased in spleen, thymus and lung, while dolichol was increased in all organs investigated. This effect was confirmed using LXR-agonist GW 3965. Analysis of CoQ distribution in organelles showed that the modifications are present in all cellular compartments and that the increase of the lipid in mitochondria was the result of a net increase of CoQ without changing the number of mitochondria. It appears that LXR influences not only cellular cholesterol homeostasis but also the metabolism of CoQ and dolichol, in an indirect manner.

Original languageEnglish (US)
Pages (from-to)299-308
Number of pages10
JournalMolecular Membrane Biology
Volume29
Issue number7
DOIs
StatePublished - Nov 1 2012

Keywords

  • Cholesterol
  • Coenzyme Q
  • Dolichol
  • Liver-X-receptor
  • Membrane modification

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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