Influence of different doses of naloxone on hemorrhagic shock in rats

Eugene V. Golanov, S. B. Parin, V. V. Suchkov

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5 Scopus citations

Abstract

Experiments on 52 Wistar rats were made to induce hemorrhagic shock by exemption of 40% blood from the jugular vein, which was followed by intravenous injection of either psychological solution or naloxone in doses of 0.4 and 1 mg/kg. Naloxone in a dose of 1 mg/kg was found to improve the animal's status as compared with the control (injection of physiological solution). On the contrary, injection of naloxone in a dose of 0.4 mg/kg led to the deterioration of the animal's status. Based on these data it is suggested that different opiate receptors play an inconclusive role in the development and progress of hemorrhagic shock induced by acute hemorrhage.

Original languageEnglish (US)
Pages (from-to)70-73
Number of pages4
JournalByulleten Eksperimentalnoi Biologii i Meditsiny
Volume96
Issue number10
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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