Inflammation, innate immunity and blood coagulation

F. Lupu, Charles T. Esmon

Research output: Contribution to journalReview articlepeer-review

160 Scopus citations


Inflammation drives arterial, venous and microvascular thrombosis. Chronic inflammation contributes to arterial thrombotic complications, whereas acute inflammation drives venous thrombosis and microvascular thrombosis. Mechanistically, inflammation modulates thrombotic responses by upregulating procoagulants, downregulating anticoagulants and suppressing fibrinolysis. The inflammatory response can also result in cell apoptosis or necrosis. Products released from the dead cells, particularly histones, propagate further inflammation, tissue death and organ failure. Inhibition of histone mediated cytotoxicity appears to be a new mechanism for protecting against this deadly cascade.

Original languageEnglish (US)
Pages (from-to)5-9
Number of pages5
Issue number1
StatePublished - Mar 16 2010
Externally publishedYes


  • Inflammation
  • Multiorgan failure
  • Sepsis
  • Thrombosis

ASJC Scopus subject areas

  • Medicine(all)
  • Hematology


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