Inflammation in atherosclerosis and implications for therapy

Rodolfo Paoletti, Antonio M. Gotto, David P. Hajjar

Research output: Contribution to journalReview article

256 Scopus citations

Abstract

Atherosclerosis is now understood to be a disease characterized by inflammation that results in a host of complications, including ischemia, acute coronary syndromes (unstable angina pectoris and myocardial infarction), and stroke. Inflammation may be caused by a response to oxidized low-density lipoproteins, chronic infection, or other factors; and markers of this process, such as C-reactive protein, may be useful to predict an increased risk of coronary heart disease. Thus, we believe that inflammatory processes may be potential targets of therapy in preventing or treating atherosclerosis and its complications.

Original languageEnglish (US)
Pages (from-to)III20-III26
JournalCirculation
Volume109
Issue number23 SUPPL.
StatePublished - Jun 15 2004

Keywords

  • Atherosclerosis
  • C-reactive protein
  • Coronary heart disease
  • Inflammation
  • Risk factors

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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