Inflammation and lung cancer: The link to angiogenesis

Tina Ei Rayes, Raul Catena, Shahin Rafii, Nasser Altorki, Vivek Mittal

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Emerging studies have begun to strengthen the link between chronic inflammation and cancer. Inflammation is now accepted as an underlying or enabling characteristic that contributes to key hallmarks of cancer, and nonsteroidal antiinflammatory drugs (NSAID) have shown a reduction in the risk of several cancers. In lung cancer patients, pulmonary disorders, such as chronic obstructive pulmonary disease (COPD) and emphysema, constitute comorbid conditions and comprise an independent risk factor for lung cancer. Despite the clinical association, the mechanistic link between COPD and lung cancer is not completely understood and constitutes an area of intense investigation. Notably, chronic inflammation appears to be a pivotal pathological feature in both COPD and lung cancer. The inflammatory microenvironment encountered in COPD/emphysema may contribute to tumorigenesis via several possible signaling pathways, including angiogenesis. Accumulating evidence suggests that angiogenesis is closely linked to inflammation, with regulators of angiogenesis playing key roles in various inflammatory conditions and vice versa. Inflammatory cells, namely neutrophils, mast cells, monocytes/macrophages, and lymphocytes, play an active role in enhancing tumor angiogenesis by secreting chemokines, inflammatory cytokines, and proteases into the local microenvironment that control endothelial cell (EC) activation by virtue of regulating proliferation, survival and apoptosis, and migration. Therefore, targeting the inflammatory and angiogenic pathways provides unique opportunities for both prevention and treatment of lung cancer.

Original languageEnglish (US)
Title of host publicationInflammation and Lung Cancer
PublisherSpringer New York
Pages137-159
Number of pages23
ISBN (Electronic)9781493927241
ISBN (Print)9781493927234
DOIs
StatePublished - Jan 1 2015

Keywords

  • Angiogenesis
  • Bone marrow
  • COPD
  • Cytokines
  • Endothelial cells
  • Hypoxia
  • Inflammation
  • Lung cancer
  • Therapy

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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