TY - GEN
T1 - Inflamed leukocyte-mimetic nanoparticles for molecular imaging of inflammation
T2 - 2011 AIChE Annual Meeting, 11AIChE
AU - Chen, Xiaoyue
AU - Wong, Richard
AU - Khalidov, Ildar
AU - Wang, Y. Andrew
AU - Leelawattanachai, Jeerapond
AU - Wang, Yi
AU - Jin, Moonsoo M.
PY - 2011
Y1 - 2011
N2 - This study presents physiology-inspired design of superparamagnetic iron oxide (SPIO) nanoparticles for in vivo detection by optical imaging and MRI, mimicking activated leukocyte in its ability to recognize inflamed endothelium. Nanoparticles in vivo will experience hydrodynamic force induced by the blood flow, requiring simultaneous molecular interactions with sufficient adhesion strength with the cells for nanoparticles to remain on the cell surface. Therefore, the design of nanoparticles with tunable affinity and avidity of physiological interactions would be critical to the selectivity and efficiency of targeting. Here we demonstrate specific accumulation of systemically- delivered nanoparticles mimicking the behavior of inflamed leukocytes into tumor cells overexpressing ICAM-1 and the surrounding vascular microenvironment. Further findings of our leukocyte-mimetic nanoparticles (LMN) localizing to the inflamed vasculature of tumors expressing low level of ICAM-1 highlight a potential use of LMN for detection of tumor growth by their accumulation into the inflammatory tumor microenvironment, irrespective of the type of tumor surface antigen.
AB - This study presents physiology-inspired design of superparamagnetic iron oxide (SPIO) nanoparticles for in vivo detection by optical imaging and MRI, mimicking activated leukocyte in its ability to recognize inflamed endothelium. Nanoparticles in vivo will experience hydrodynamic force induced by the blood flow, requiring simultaneous molecular interactions with sufficient adhesion strength with the cells for nanoparticles to remain on the cell surface. Therefore, the design of nanoparticles with tunable affinity and avidity of physiological interactions would be critical to the selectivity and efficiency of targeting. Here we demonstrate specific accumulation of systemically- delivered nanoparticles mimicking the behavior of inflamed leukocytes into tumor cells overexpressing ICAM-1 and the surrounding vascular microenvironment. Further findings of our leukocyte-mimetic nanoparticles (LMN) localizing to the inflamed vasculature of tumors expressing low level of ICAM-1 highlight a potential use of LMN for detection of tumor growth by their accumulation into the inflammatory tumor microenvironment, irrespective of the type of tumor surface antigen.
UR - http://www.scopus.com/inward/record.url?scp=84863069623&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863069623&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84863069623
SN - 9780816910700
T3 - AIChE Annual Meeting, Conference Proceedings
BT - 11AIChE - 2011 AIChE Annual Meeting, Conference Proceedings
Y2 - 16 October 2011 through 21 October 2011
ER -