Abstract
The discovery of regulatory networks is an important aspect in the post genomic research. The process requires integrated efforts of experimental and computational strategies by employing the systems biology approach. This review summarizes some of the major themes in computational inference of regulatory networks based on gene expression and other data sources, including transcriptional module identification, network topology inference, and network analysis. Popular solutions to each of these problems and their relative merits are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 263-275 |
| Number of pages | 13 |
| Journal | Frontiers in Bioscience |
| Volume | 13 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2008 |
Keywords
- Coexpression
- Modeling and inference
- Pathway dynamics
- Regulatory network
- Review
- Systems biology
- Transcriptional intervention
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
- Biochemistry
- Cell Biology
- General Medicine