Induction of glutathione S-transferases in genetically inbred male mice by dietary ethoxyquin hydrochloride

M. Makary; H. L. Kim; S. Safe; J. Womack; G. W. Ivie

doi:10.1016/0742-8413(89)90035-2

Induction of glutathione S-transferases in genetically inbred male mice by dietary ethoxyquin hydrochloride

M. Makary, H. L. Kim, S. Safe, J. Womack, G. W. Ivie

Research output: Contribution to journal › Article › peer-review

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Abstract

1. Constitutive and ethoxyquin hydrochloride (EQ-HCl)-induced hepatic glutathione (GSH) S-transferase, GSH reductase, and GSH peroxidase activities were determined in 5 strains of 8–10 week old inbred male mice. 2. The constitutive GSH S-transferase (GST) activity varied from 2.9 (SJL/JCR) to 8.9 (C57BL/6NCR) μmol product formed/min/mg protein and the corresponding values for the EQ-HCl-treated mice were in the range of 15.3–25.3 μmol product formed/min/mg protein. 3. EQ-HCl nduced GST activity in all the strains examined and this contrasted to the induction activity of Aroclor 1254 which was strain-dependent. GST activity was induced 2.9-fold in Aroclor 1254-responsive (C57BL/6) and 2.8-fold in non-responsive (DBA/2) mice, respectively.

Original language	English (US)
Pages (from-to)	171-174
Number of pages	4
Journal	Comparative Biochemistry and Physiology. Part C, Comparative
Volume	92
Issue number	2
DOIs	https://doi.org/10.1016/0742-8413(89)90035-2
State	Published - 1989

ASJC Scopus subject areas

Immunology
Pharmacology

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title = "Induction of glutathione S-transferases in genetically inbred male mice by dietary ethoxyquin hydrochloride",

abstract = "1. Constitutive and ethoxyquin hydrochloride (EQ-HCl)-induced hepatic glutathione (GSH) S-transferase, GSH reductase, and GSH peroxidase activities were determined in 5 strains of 8\–10 week old inbred male mice. 2. The constitutive GSH S-transferase (GST) activity varied from 2.9 (SJL/JCR) to 8.9 (C57BL/6NCR) \μmol product formed/min/mg protein and the corresponding values for the EQ-HCl-treated mice were in the range of 15.3\–25.3 \μmol product formed/min/mg protein. 3. EQ-HCl nduced GST activity in all the strains examined and this contrasted to the induction activity of Aroclor 1254 which was strain-dependent. GST activity was induced 2.9-fold in Aroclor 1254-responsive (C57BL/6) and 2.8-fold in non-responsive (DBA/2) mice, respectively.",

author = "M. Makary and Kim, \{H. L.\} and S. Safe and J. Womack and Ivie, \{G. W.\}",

year = "1989",

doi = "10.1016/0742-8413(89)90035-2",

language = "English (US)",

volume = "92",

pages = "171--174",

journal = "Comparative Biochemistry and Physiology. Part C, Comparative",

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TY - JOUR

T1 - Induction of glutathione S-transferases in genetically inbred male mice by dietary ethoxyquin hydrochloride

AU - Makary, M.

AU - Kim, H. L.

AU - Safe, S.

AU - Womack, J.

AU - Ivie, G. W.

PY - 1989

Y1 - 1989

N2 - 1. Constitutive and ethoxyquin hydrochloride (EQ-HCl)-induced hepatic glutathione (GSH) S-transferase, GSH reductase, and GSH peroxidase activities were determined in 5 strains of 8–10 week old inbred male mice. 2. The constitutive GSH S-transferase (GST) activity varied from 2.9 (SJL/JCR) to 8.9 (C57BL/6NCR) μmol product formed/min/mg protein and the corresponding values for the EQ-HCl-treated mice were in the range of 15.3–25.3 μmol product formed/min/mg protein. 3. EQ-HCl nduced GST activity in all the strains examined and this contrasted to the induction activity of Aroclor 1254 which was strain-dependent. GST activity was induced 2.9-fold in Aroclor 1254-responsive (C57BL/6) and 2.8-fold in non-responsive (DBA/2) mice, respectively.

AB - 1. Constitutive and ethoxyquin hydrochloride (EQ-HCl)-induced hepatic glutathione (GSH) S-transferase, GSH reductase, and GSH peroxidase activities were determined in 5 strains of 8–10 week old inbred male mice. 2. The constitutive GSH S-transferase (GST) activity varied from 2.9 (SJL/JCR) to 8.9 (C57BL/6NCR) μmol product formed/min/mg protein and the corresponding values for the EQ-HCl-treated mice were in the range of 15.3–25.3 μmol product formed/min/mg protein. 3. EQ-HCl nduced GST activity in all the strains examined and this contrasted to the induction activity of Aroclor 1254 which was strain-dependent. GST activity was induced 2.9-fold in Aroclor 1254-responsive (C57BL/6) and 2.8-fold in non-responsive (DBA/2) mice, respectively.

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UR - https://www.scopus.com/inward/citedby.url?scp=0024594843&partnerID=8YFLogxK

U2 - 10.1016/0742-8413(89)90035-2

DO - 10.1016/0742-8413(89)90035-2

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AN - SCOPUS:0024594843

SN - 0306-4492

VL - 92

SP - 171

EP - 174

JO - Comparative Biochemistry and Physiology. Part C, Comparative

JF - Comparative Biochemistry and Physiology. Part C, Comparative

IS - 2

ER -

Induction of glutathione S-transferases in genetically inbred male mice by dietary ethoxyquin hydrochloride

Abstract

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