Induction of glutathione S-transferases in genetically inbred male mice by dietary ethoxyquin hydrochloride

M. Makary, H. L. Kim, S. Safe, J. Womack, G. W. Ivie

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

1. Constitutive and ethoxyquin hydrochloride (EQ-HCl)-induced hepatic glutathione (GSH) S-transferase, GSH reductase, and GSH peroxidase activities were determined in 5 strains of 8–10 week old inbred male mice. 2. The constitutive GSH S-transferase (GST) activity varied from 2.9 (SJL/JCR) to 8.9 (C57BL/6NCR) μmol product formed/min/mg protein and the corresponding values for the EQ-HCl-treated mice were in the range of 15.3–25.3 μmol product formed/min/mg protein. 3. EQ-HCl nduced GST activity in all the strains examined and this contrasted to the induction activity of Aroclor 1254 which was strain-dependent. GST activity was induced 2.9-fold in Aroclor 1254-responsive (C57BL/6) and 2.8-fold in non-responsive (DBA/2) mice, respectively.

Original languageEnglish (US)
Pages (from-to)171-174
Number of pages4
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume92
Issue number2
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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