Induction and regulation of the IgE response

David Corry; Farrah Kheradmand

doi:10.1038/35037014

Induction and regulation of the IgE response

David Corry, Farrah Kheradmand

Research output: Contribution to journal › Review article › peer-review

281 Scopus citations

Abstract

Immunoglobulin E (IgE) is believed to be one of the major mediators of immediate hypersensitivity reactions that underlie atopic conditions such as urticaria, seasonal allergy, asthma and anaphylaxis. Factors that control IgE production are therefore essential to the pathogenesis of these important afflictions. But a complete understanding of this topic is lacking, while new data have raised questions regarding the precise role of IgE in atopic disease. Evolving concepts of IgE production and elimination are likely to clarify the importance of IgE in health and disease.

Original language	English (US)
Pages (from-to)	B18-B23
Journal	Nature
Volume	402
Issue number	6760 SUPPL. 1
DOIs	https://doi.org/10.1038/35037014
State	Published - Nov 25 1999

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AB - Immunoglobulin E (IgE) is believed to be one of the major mediators of immediate hypersensitivity reactions that underlie atopic conditions such as urticaria, seasonal allergy, asthma and anaphylaxis. Factors that control IgE production are therefore essential to the pathogenesis of these important afflictions. But a complete understanding of this topic is lacking, while new data have raised questions regarding the precise role of IgE in atopic disease. Evolving concepts of IgE production and elimination are likely to clarify the importance of IgE in health and disease.

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Induction and regulation of the IgE response

Abstract

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