Induction and regulation of the IgE response

David Corry, Farrah Kheradmand

Research output: Contribution to journalReview articlepeer-review

246 Scopus citations

Abstract

Immunoglobulin E (IgE) is believed to be one of the major mediators of immediate hypersensitivity reactions that underlie atopic conditions such as urticaria, seasonal allergy, asthma and anaphylaxis. Factors that control IgE production are therefore essential to the pathogenesis of these important afflictions. But a complete understanding of this topic is lacking, while new data have raised questions regarding the precise role of IgE in atopic disease. Evolving concepts of IgE production and elimination are likely to clarify the importance of IgE in health and disease.

Original languageEnglish (US)
Pages (from-to)B18-B23
JournalNature
Volume402
Issue number6760 SUPPL. 1
DOIs
StatePublished - Nov 25 1999

ASJC Scopus subject areas

  • General

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