Induced pluripotent stem cells in Alzheimer's disease: Applications for disease modeling and cell-replacement therapy

Juan Yang, Song Li, Xi Biao He, Cheng Cheng, Weidong Le

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

Alzheimer's disease (AD) is the most common cause of dementia in those over the age of 65. While a numerous of disease-causing genes and risk factors have been identified, the exact etiological mechanisms of AD are not yet completely understood, due to the inability to test theoretical hypotheses on non-postmortem and patient-specific research systems. The use of recently developed and optimized induced pluripotent stem cells (iPSCs) technology may provide a promising platform to create reliable models, not only for better understanding the etiopathological process of AD, but also for efficient anti-AD drugs screening. More importantly, human-sourced iPSCs may also provide a beneficial tool for cell-replacement therapy against AD. Although considerable progress has been achieved, a number of key challenges still require to be addressed in iPSCs research, including the identification of robust disease phenotypes in AD modeling and the clinical availabilities of iPSCs-based cell-replacement therapy in human. In this review, we highlight recent progresses of iPSCs research and discuss the translational challenges of AD patients-derived iPSCs in disease modeling and cell-replacement therapy.

Original languageEnglish (US)
Article number39
JournalMolecular Neurodegeneration
Volume11
Issue number1
DOIs
StatePublished - May 17 2016

Keywords

  • Alzheimer's disease
  • Cell-replacement therapy
  • Disease modeling
  • Drugs screening
  • Induced pluripotent stem cells

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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