Individually resolved DNA molecules stretched and embedded in electrospun polymer nanofibers

Leon M. Bellan; Joshua D. Cross; Elizabeth A. Strychalski; Jose Moran-Mirabal; H. G. Craighead

doi:10.1021/nl061894+

Individually resolved DNA molecules stretched and embedded in electrospun polymer nanofibers

Leon M. Bellan, Joshua D. Cross, Elizabeth A. Strychalski, Jose Moran-Mirabal, H. G. Craighead

Academic Institute

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

We have used the flow characteristics of an electrospinning jet to elongate and fix DNA molecules. We embedded and observed fluorescently labeled A bacteriophage DNA molecules in polyethylene oxide nanofibers. The embedded DNA molecules were imaged using fluorescence microscopy and found to be stretched to lengths approaching the full dyed contour length.

Original language	English (US)
Pages (from-to)	2526-2530
Number of pages	5
Journal	Nano Letters
Volume	6
Issue number	11
DOIs	https://doi.org/10.1021/nl061894+
State	Published - Nov 2006

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl061894+

Cite this

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title = "Individually resolved DNA molecules stretched and embedded in electrospun polymer nanofibers",

abstract = "We have used the flow characteristics of an electrospinning jet to elongate and fix DNA molecules. We embedded and observed fluorescently labeled A bacteriophage DNA molecules in polyethylene oxide nanofibers. The embedded DNA molecules were imaged using fluorescence microscopy and found to be stretched to lengths approaching the full dyed contour length.",

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AU - Bellan, Leon M.

AU - Cross, Joshua D.

AU - Strychalski, Elizabeth A.

AU - Moran-Mirabal, Jose

AU - Craighead, H. G.

PY - 2006/11

Y1 - 2006/11

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AB - We have used the flow characteristics of an electrospinning jet to elongate and fix DNA molecules. We embedded and observed fluorescently labeled A bacteriophage DNA molecules in polyethylene oxide nanofibers. The embedded DNA molecules were imaged using fluorescence microscopy and found to be stretched to lengths approaching the full dyed contour length.

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Individually resolved DNA molecules stretched and embedded in electrospun polymer nanofibers

Abstract

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