Individually resolved DNA molecules stretched and embedded in electrospun polymer nanofibers

Leon M. Bellan, Joshua D. Cross, Elizabeth A. Strychalski, Jose Moran-Mirabal, Harold G. Craighead

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

We have used the flow characteristics of an electrospinning jet to elongate and fix DNA molecules. We embedded and observed fluorescently labeled A bacteriophage DNA molecules in polyethylene oxide nanofibers. The embedded DNA molecules were imaged using fluorescence microscopy and found to be stretched to lengths approaching the full dyed contour length.

Original languageEnglish (US)
Pages (from-to)2526-2530
Number of pages5
JournalNano Letters
Volume6
Issue number11
DOIs
StatePublished - Nov 1 2006

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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