Individualizing antimetabolic treatment strategies for head and neck squamous cell carcinoma based on TP53 mutational status

Keyphrases

• Treatment Strategy 100%
• Tumor Protein p53 (TP53) 100%
• Head-and-neck Squamous Cell Carcinoma (HNSCC) 100%
• Mutational Status 100%
• Squamous Carcinoma Cells 63%
• Radiation Toxicity 36%
• Glycolysis Inhibition 36%
• Mitochondrial Respiration 27%
• Radioresistance 18%
• Glycolysis 18%
• Glycolytic 18%
• Radiation Therapy 9%
• External Beam Radiation 9%
• Tumor Suppressor Gene 9%
• Therapeutic Approaches 9%
• Clonogenic Assay 9%
• Carcinoma Cell Lines 9%
• Potentiating Effect 9%
• Cell Resistance 9%
• Glycolytic Flux 9%
• Treatment Selection 9%
• Tumor Metabolism 9%
• Relative Sensitivity 9%
• Potentiation 9%
• Metformin 9%
• Mitochondrial Complex IV 9%
• Mitochondrial Complex II 9%
• Metabolic Shift 9%
• Respiration Inhibition 9%
• Metabolic Drugs 9%

Medicine and Dentistry

• Head and Neck Squamous Cell Carcinoma 100%
• Tumor Protein 100%
• Squamous Cell Carcinoma Cell 60%
• Radiation Toxicity 40%
• Mitochondrial Respiration 30%
• Radiosensitivity 20%
• Radiation Therapy 10%
• Tumor Cell 10%
• Protein P53 10%
• Cell Metabolism 10%
• External Beam Radiotherapy 10%
• Tumor Suppressor Gene 10%
• Clonogenic Assay 10%
• Glycon 10%
• Metabolic Agent 10%
• Head and Neck Squamous Cell Carcinoma Cell Line 10%

Biochemistry, Genetics and Molecular Biology

• Mitochondrial Respiration 100%
• Radiosensitivity 66%
• Wild Type 33%
• Cell Metabolism 33%
• P53 33%
• Tumor Suppressor Gene 33%
• Clonogenic Assay 33%
• Radiation Beam 33%