Indium-111-oxinate labeled swine platelets and their survival in vivo.

S. S. Zoghbi, M. L. Thakur, Henry Dirk Sostman, R. H. Greenspan, A. Gottschalk

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Since the fibrinolytic system of the swine is close to that of human, the use of a swine model may assume increasing prominence in future studies of thrombosis. Swine platelets were labeled with 111In in a modified Tyrode's solution, suspended in plasma, then injected intravenously into swine. The average radioactivity incorporated into the platelets was 44 +/- 27%. The recovery of labeled platelets at 5 minutes post-injection was 81.7 +/- 5.3%. The platelets retained their label throughout their life span. The survival of 111In-platelets was described by a one component exponential equation, with a life span of 157.9 +/- 25.3 hrs.

Original languageEnglish (US)
Pages (from-to)444-447
Number of pages4
JournalLaboratory animal science
Volume38
Issue number4
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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