Indium-111-oxinate labeled swine platelets and their survival in vivo.

S. S. Zoghbi; M. L. Thakur; Henry Dirk Sostman; R. H. Greenspan; A. Gottschalk

Indium-111-oxinate labeled swine platelets and their survival in vivo.

S. S. Zoghbi, M. L. Thakur, Henry Dirk Sostman, R. H. Greenspan, A. Gottschalk

Research output: Contribution to journal › Article › peer-review

Abstract

Since the fibrinolytic system of the swine is close to that of human, the use of a swine model may assume increasing prominence in future studies of thrombosis. Swine platelets were labeled with 111In in a modified Tyrode's solution, suspended in plasma, then injected intravenously into swine. The average radioactivity incorporated into the platelets was 44 +/- 27%. The recovery of labeled platelets at 5 minutes post-injection was 81.7 +/- 5.3%. The platelets retained their label throughout their life span. The survival of 111In-platelets was described by a one component exponential equation, with a life span of 157.9 +/- 25.3 hrs.

Original language	English (US)
Pages (from-to)	444-447
Number of pages	4
Journal	Laboratory animal science
Volume	38
Issue number	4
State	Published - Jan 1 1988

ASJC Scopus subject areas

Animal Science and Zoology
General Veterinary

Cite this

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title = "Indium-111-oxinate labeled swine platelets and their survival in vivo.",

abstract = "Since the fibrinolytic system of the swine is close to that of human, the use of a swine model may assume increasing prominence in future studies of thrombosis. Swine platelets were labeled with 111In in a modified Tyrode's solution, suspended in plasma, then injected intravenously into swine. The average radioactivity incorporated into the platelets was 44 +/- 27%. The recovery of labeled platelets at 5 minutes post-injection was 81.7 +/- 5.3%. The platelets retained their label throughout their life span. The survival of 111In-platelets was described by a one component exponential equation, with a life span of 157.9 +/- 25.3 hrs.",

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AU - Sostman, Henry Dirk

AU - Greenspan, R. H.

AU - Gottschalk, A.

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N2 - Since the fibrinolytic system of the swine is close to that of human, the use of a swine model may assume increasing prominence in future studies of thrombosis. Swine platelets were labeled with 111In in a modified Tyrode's solution, suspended in plasma, then injected intravenously into swine. The average radioactivity incorporated into the platelets was 44 +/- 27%. The recovery of labeled platelets at 5 minutes post-injection was 81.7 +/- 5.3%. The platelets retained their label throughout their life span. The survival of 111In-platelets was described by a one component exponential equation, with a life span of 157.9 +/- 25.3 hrs.

AB - Since the fibrinolytic system of the swine is close to that of human, the use of a swine model may assume increasing prominence in future studies of thrombosis. Swine platelets were labeled with 111In in a modified Tyrode's solution, suspended in plasma, then injected intravenously into swine. The average radioactivity incorporated into the platelets was 44 +/- 27%. The recovery of labeled platelets at 5 minutes post-injection was 81.7 +/- 5.3%. The platelets retained their label throughout their life span. The survival of 111In-platelets was described by a one component exponential equation, with a life span of 157.9 +/- 25.3 hrs.

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Indium-111-oxinate labeled swine platelets and their survival in vivo.

Abstract

ASJC Scopus subject areas

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