Incremental prognostic value of positron emission tomography derived left ventricular mass

Ahmed Ibrahim Ahmed, Jean Michel Saad, Yushui Han, Maan Malahfji, Mouaz H. Al-Mallah

Research output: Contribution to journalArticlepeer-review


Background: Left ventricular hypertrophy has been shown to be an independent predictor of outcomes in patients with coronary artery disease (CAD). We aimed to determine the incremental prognostic value of positron emission tomography (PET) derived left ventricular mass (LVM) to clinical variables and myocardial flow reserve (MFR). Methods: We included consecutive patients who had clinically indicated PET myocardial perfusion imaging for suspected or established CAD. Patients were followed from the date of PET imaging for major adverse cardiovascular events (MACE, inclusive of all-cause death, non-fatal myocardial infarction, and percutaneous coronary intervention/coronary artery bypass grafting 90 days after imaging). Results: A total of 2357 patients underwent PET MPI during the study period (47% female, mean age 66 ± 12 years, 87% hypertensive, 47% diabetic, 79% dyslipidemia). After a mean follow-up of 11.6 ± 6.6 months, 141 patients (6.0%, 5.1 per 1000 person-year) experienced MACE (86 D/24 MI/39 PCI/9 CABG). In nested multivariable Cox models, LVM was not independently associated with outcomes (HR 1.00, P = .157) and had no incremental prognostic value (C index: 0.75, P = .571) over MFR and clinical variables. Conclusion: Our analysis shows that LVM provides no independent and incremental prognostic value over MFR and clinical variables.

Original languageEnglish (US)
Pages (from-to)254-263
Number of pages10
JournalJournal of Nuclear Cardiology
Issue number1
StatePublished - Feb 2023


  • Left ventricular mass
  • PET
  • left ventricular hypertrophy
  • Percutaneous Coronary Intervention/adverse effects
  • Predictive Value of Tests
  • Myocardial Perfusion Imaging/methods
  • Prognosis
  • Humans
  • Middle Aged
  • Myocardial Infarction/complications
  • Male
  • Coronary Artery Disease
  • Female
  • Aged
  • Positron-Emission Tomography/methods

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging


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