Increased serum thyroglobulin levels and negative imaging in thyroid cancer patients: Are there sources of benign secretion? A speculative short review

Paolo Zanotti-Fregonara, Isabelle Keller, Marie Calzada-Nocaudie, Adil Al-Nahhas, Jean Yves Devaux, Gaia Grassetto, Maria Cristina Marzola, Domenico Rubello, Elif Hindié

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

After thyroidectomy and 131I ablation for differentiated thyroid cancer (DTC), serum thyroglobulin (Tg) became a sensitive marker of residual disease. It is not uncommon to find patients at follow-up with persistent serum Tg levels and no other clinical or imaging evidence for the disease. The vast majority of these patients, most probably, have occult foci of disease, often in minute cervical lymph nodes. A review of the literature including papers published on PubMed/Medline until June 2010 was made. In this study we speculated that a minority of patients who had undergone surgery for differentiated thyroid cancer might have benign sources of Tg secretion at follow-up. These sources may be foci of radio-resistant ectopic thyroid tissue or a thyroid stimulating hormone-stimulated thymus.

Original languageEnglish (US)
Pages (from-to)1054-1058
Number of pages5
JournalNuclear medicine communications
Volume31
Issue number12
DOIs
StatePublished - Dec 1 2010

Keywords

  • benign sources of thyroglobulin production
  • differentiated thyroid cancer
  • follow-up
  • serum thyroglobulin levels

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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