@article{3dcd725012ec42809f04603c994961bb,
title = "Increased phosphorylated components of erythrocyte membrane spectrin band II with reference to Duchenne muscular dystrophy",
abstract = "Increased erythrocyte band II phosphorylation has been demonstrated in patients with Duchenne muscular dystrophy (DMD). Band II has been purified by preparative sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis. Isoelectric focusing of purified band II from which SDS has been removed reveals heterogeneity. Band II migrates as multiple bands on isoelectric focusing gels and as a single band on SDS-polyacrylamide gels. The increased phosphorylation in DMD does not occur uniformly in all components of band II. Highly phosphorylated components of band II are present in DMD in which only minimal phosphorylation occurs in controls. These results suggest the presence of an abnormal band II substrate in erythrocyte membranes from DMD patients.",
author = "Roses, {A. D.} and M. Herbstreith and B. Metcalf and Appel, {S. H.}",
note = "Funding Information: In many human inborn errors of metabolism that involve the central nervous system or neuromuscular tissue, plasma, peripheral white blood cells or cultured skin fibroblasts can be used to study the primary enzymatic defect (Kampine, Brady, Kanfer, Feld and Shapiro 1967; Tauri, Knok, Nasu and Nishikawa 1969; Steinberg 1972; Nyhan 1973). The human red blood cell offers similar advantages in inherited disorders which involve membranes and for which no adequate animal models exist This work has been presented in part at the Fifth Annual Meeting of the Society for Neuroscience in New York, N.Y., 2-6 November, 1975, where it was published as Abstract 960 in Neuroscience Abstracts, 1975. This work was supported by grant CRU RR-30 from the General Clinical Research Centers Program of the Division of Research Resources, National Institute of Health, National Institute of Health Grant No. HS12213 and Basil O'Conner Starter Grant No. 5-36 from the National Foundation March of Dimes. A.D.R. is a recipient of a Research Career Development Award from the National Institute of Neurological and Communicative Disorders and Stroke. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",
year = "1976",
month = nov,
doi = "10.1016/0022-510X(76)90264-1",
language = "English (US)",
volume = "30",
pages = "167--178",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",
number = "1",
}