Increased in vivo expression of an inflammatory marker in temporal lobe epilepsy

Jussi Hirvonen, William C. Kreisl, Masahiro Fujita, Irene Dustin, Omar Khan, Shmuel Appel, Yi Zhang, Cheryl Morse, Victor W. Pike, Robert B. Innis, William H. Theodore

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Animal studies and clinical observations suggest that epilepsy is associated with inflammation. Translocator protein (TSPO) (18 kDa), a marker of inflammation, is increased in vitro in surgical samples from patients with temporal lobe epilepsy. TSPO can be measured in the living human brain with PET and the novel radioligand 11C-PBR28. In this study, we sought to determine whether in vivo expression of TSPO is increased ipsilateral to the seizure focus in patients with temporal lobe epilepsy. Methods: Sixteen patients with unilateral temporal lobe epilepsy and 30 healthy subjects were studied with 11C-PBR28 PET and MRI. Uptake of radioactivity after injection of 11C-PBR28 was measured from regions of interest drawn bilaterally onto MR images. Brain uptake from ipsilateral and contralateral hemispheres was compared using a paired-samples t test. Results: We found that brain uptake was higher ipsilateral to the seizure focus in the hippocampus, parahippocampal gyrus, amygdala, fusiform gyrus, and choroid plexus but not in other brain regions. This asymmetry was more pronounced in patients with hippocampal sclerosis than in those without. Conclusion: We found increased uptake of radioactivity after injection of 11C-PBR28 ipsilateral to the seizure focus in patients with temporal lobe epilepsy, suggesting increased expression of TSPO. Studies in larger samples are required to confirm this finding and determine the clinical utility of imaging TSPO in temporal lobe epilepsy.

Original languageEnglish (US)
Pages (from-to)234-240
Number of pages7
JournalJournal of Nuclear Medicine
Volume53
Issue number2
DOIs
StatePublished - Feb 1 2012

Keywords

  • Epilepsy
  • Inflammation
  • Positron emission tomography
  • Translocator protein 18 kDa

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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