Increased CSF glutamate following injection of ALS immunoglobulins

Vincenzo La Bella, J. Clay Goodman, Stanley H. Appel

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


To reconcile the autoimmune and excitotoxic hypotheses regarding the etiology of amyotrophic lateral sclerosis (ALS), we injected rats intraperitoneally with ALS immunoglobulins and monitored CSF glutamate, aspartate, glutamine, and glutathione. CSF glutamate was significantly increased at 24 and 72 hours compared with both basal levels and disease control injected rats. CSF aspartate was increased at 72 hours. Glutamine and glutathione were unchanged. These data suggest that ALS immunoglobulins may enhance CSF glutamate and aspartate levels and contribute to motoneuron injury.

Original languageEnglish (US)
Pages (from-to)1270-1272
Number of pages3
Issue number5
StatePublished - May 1997

ASJC Scopus subject areas

  • Clinical Neurology


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