TY - JOUR
T1 - Inclusion Body Myositis
T2 - A Corticosteroid-Resistant Idiopathic Inflammatory Myopathy
AU - Danon, Moris J.
AU - Reyes, Marcelino G.
AU - Perurena, Osvaldo H.
AU - Masdeu, Joseph C.
AU - Manaligod, Jose R.
PY - 1982/1/1
Y1 - 1982/1/1
N2 - In seven patients with slowly progressive muscle weakness, inclusion body myositis (IBM) was diagnosed on biopsy. None had stigmata of collagen-vascular disease of malignancy. Serum creatine kinase levels were mildly or moderately increased. The six patients treated with prednisone did not improve. Needle electromyography showed a 'myopathic' pattern in all patients, but four also had diffuse neurogenic changes with normal nerve conductions. Histologic study of muscle showed a mixture of small rounded fibers varying in size, atrophic angulated fibers forming small groups and hypertrophic fibers. Variable amounts of inflammation, necrosis, and regeneration were seen in all specimens. All showed numerous intracytoplasmic vacuoles lined with purple-blue granules. Electron microscopy showed membranous whorls and masses of abnormal filaments measuring 14 to 18 nm in diameter. Although IBM seems to be a distinct type of inflammatory myopathy, its etiology and pathogenesis are not clear.
AB - In seven patients with slowly progressive muscle weakness, inclusion body myositis (IBM) was diagnosed on biopsy. None had stigmata of collagen-vascular disease of malignancy. Serum creatine kinase levels were mildly or moderately increased. The six patients treated with prednisone did not improve. Needle electromyography showed a 'myopathic' pattern in all patients, but four also had diffuse neurogenic changes with normal nerve conductions. Histologic study of muscle showed a mixture of small rounded fibers varying in size, atrophic angulated fibers forming small groups and hypertrophic fibers. Variable amounts of inflammation, necrosis, and regeneration were seen in all specimens. All showed numerous intracytoplasmic vacuoles lined with purple-blue granules. Electron microscopy showed membranous whorls and masses of abnormal filaments measuring 14 to 18 nm in diameter. Although IBM seems to be a distinct type of inflammatory myopathy, its etiology and pathogenesis are not clear.
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U2 - 10.1001/archneur.1982.00510240022006
DO - 10.1001/archneur.1982.00510240022006
M3 - Article
C2 - 6291495
AN - SCOPUS:0020381545
VL - 39
SP - 760
EP - 764
JO - Archives of neurology
JF - Archives of neurology
SN - 0003-9942
IS - 12
ER -