Incidence, Predictors, and Outcomes of New-Onset Left Ventricular Systolic Dysfunction After Orthotopic Liver Transplantation

Vaughn A. Eyvazian, Jonathan S. Gordin, Eric H. Yang, Olcay Aksoy, Henry M. Honda, Ronald W. Busuttil, Vatche G. Agopian, Gabriel Vorobiof

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Background: Adverse cardiovascular events after liver transplantation (LT) are relatively common and are a significant source of early mortality. Although new-onset systolic dysfunction after LT is a reported phenomenon, there is little data regarding its incidence, risk factors, and outcomes. Methods and Results: This single-center retrospective study included all adult patients from January 2002 to March 2015 with deceased-donor LT and available preoperative transthoracic echocardiograms (TTEs). In total, 1,760 patients were included in the study, 602 (34.2%) of whom had a postoperative TTE. The primary end point was development of new-onset cardiomyopathy, defined as a new left ventricular ejection fraction (LVEF) of <40% within 180days of transplant. Sixty-nine (11.4%) of the patients who received post-LT TTE had a reduction in LVEF to <40% within 6 months. Clinical parameters of donor and recipient did not show significant impact on development of post-LT LV systolic dysfunction (LVSD). Presence of wall motion abnormalities (P =.004) on preoperative TTE was predictive of development of post-LT LVSD. These patients did not have longer hospitalizations, but they had worse survival. Conclusions: Post-LT LV systolic dysfunction occurs at higher rates than previously suspected and may develop more frequently in patients with underlying cardiac structural abnormalities, which appear to adversely affect post-LT survival.

Original languageEnglish (US)
Pages (from-to)166-172
Number of pages7
JournalJournal of Cardiac Failure
Issue number3
StatePublished - Mar 2019


  • Left ventricular systolic dysfunction
  • heart failure
  • liver transplant

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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