Incidence of Lymph Node Metastases in Women With Low-Risk Early Cervical Cancer (<2 cm) Without Lymph-Vascular Invasion

Lucas Minig, Anna Fagotti, Giovanni Scambia, Gloria Salvo, María Guadalupe Patrono, Dimitrios Haidopoulos, Ignacio Zapardiel, Santiago Domingo, Maria Sotiropoulou, Gary Chisholm, Pedro T. Ramirez

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Objective: To determine the incidence of lymph node metastasis in women with low-risk cervical cancer stage IA2 or IB1 (<2 cm) without lymph-vascular space invasion. Methods: A multicenter retrospective study was performed in patients who underwent radical or simple hysterectomy, conization, or trachelectomy plus pelvic lymphadenectomy for cervical cancer between January 2000 and June 2016. Results: A total of 271 patients were included in the study. Median age and body mass index were 46 years (range, 23-77 years) and 24 kg/m 2 (range, 18-48 kg/m 2 ), respectively. Twenty-two patients had stage IA2 (8.1%), and 249 (91.9%) had stage IB1. The median tumor size was 14 mm (range, 5-20 mm). Tumor grades were 1 (n = 63 [23.2%]), 2 (n = 120 [44.3%]), 3 (n = 63 [23.2%]), and unknown (25 [9.2%]). Median depth stromal invasion was 6 mm (range, 3-20 mm). Histologic subtypes included squamous (n = 171 [63.1%]), adenocarcinoma (n = 92 [33.9%]), and adenosquamous (n = 8 [3.0%]). Overall incidence of lymph node metastasis was 2.9% (n = 8). The incidence of lymph node involvement in G1, G2, and G3 was 0% (0/63), 5% (6/120), and 3.1% (2/63), respectively. No patient with stage IA2 (regardless of grade or histology) or G1 cervical cancer less than 2 cm (stage IB1) had lymph node metastasis. Conclusions: Patients with stage IA2 or IB1 (G1) with tumor size of less than 2 cm and no lymph-vascular space invasion may not need lymph node evaluation. On the other hand, 95% and 98% of patients with grade 2 or 3 tumors, respectively, could potentially undergo an unnecessary lymphadenectomy. Further studies with bigger sample size are required to confirm these results.

Original languageEnglish (US)
Pages (from-to)788-793
Number of pages6
JournalInternational Journal of Gynecological Cancer
Issue number4
StatePublished - May 1 2018


  • Cervical cancer
  • Early stage
  • Lymph node metastasis
  • Lymph-vascular space invasion

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


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