Incidence, Etiology and outcomes of hyponatremia after transsphenoidal surgery: Experience with 344 consecutive patients at a single tertiary center

Sean M. Barber, Brandon D. Liebelt, David S. Baskin

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Hyponatremia is often seen after transsphenoidal surgery and is a source of considerable economic burden and patient-related morbidity and mortality. We performed a retrospective review of 344 patients who underwent transsphenoidal surgery at our institution between 2006 and 2012. Postoperative hyponatremia was seen in 18.0% of patients at a mean of 3.9 days postoperatively. Hyponatremia was most commonly mild (51.6%) and clinically asymptomatic (93.8%). SIADH was the primary cause of hyponatremia in the majority of cases (n = 44, 71.0%), followed by cerebral salt wasting (n = 15, 24.2%) and desmopressin over-administration (n = 3, 4.8%). The incidence of postoperative hyponatremia was significantly higher in patients with cardiac, renal and/or thyroid disease (p = 0.0034, Objective Risk (OR) = 2.60) and in female patients (p = 0.011, OR = 2.18) or patients undergoing post-operative cerebrospinal fluid drainage (p = 0.0006). Treatment with hypertonic saline (OR = -2.4, p = 0.10) and sodium chloride tablets (OR = -1.57, p = 0.45) was associated with a non-significant trend toward faster resolution of hyponatremia. The use of fluid restriction and diuretics should be de-emphasized in the treatment of post-transsphenoidal hyponatremia, as they have not been shown to significantly alter the time-course to the restoration of sodium balance.

Original languageEnglish (US)
Pages (from-to)1199-1219
Number of pages21
JournalJournal of Clinical Medicine
Volume3
Issue number4
DOIs
StatePublished - Oct 28 2014

Keywords

  • Cerebral salt wasting
  • Hyponatremia
  • Pituitary adenoma
  • SIADH
  • Transsphenoidal

ASJC Scopus subject areas

  • Medicine(all)

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