Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism

Keyphrases

• Histone Deacetylase 1 (HDAC1) 100%
• Trehalose Metabolism 100%
• Transcriptional Activation 66%
• Histone Acetylation 33%
• Evolutionarily Conserved 33%
• Aging 33%
• Screening Method 33%
• Drosophilidae 33%
• Metabolic Pathway 33%
• Caenorhabditis Elegans 33%
• Replicative Lifespan 33%
• High-throughput Sequencing 33%
• Transcriptional Repression 33%
• Epigenetic Marks 33%
• Metabolic Changes 33%
• Repressor Complex 33%
• Trehalose 33%
• Osmotic Stress 33%
• Long Lifespan 33%
• Adult Fly 33%
• Cyc8 33%
• Tup1 33%
• H3K18 33%
• Lifespan Aging 33%
• Storage Carbohydrates 33%
• Yeast Knockout 33%
• H3K18 Acetylation 33%
• Physical Decline 33%
• Longevity Pathways 33%
• DNA Damage Stress 33%
• Delayed Aging 33%

Biochemistry, Genetics and Molecular Biology

• Metabolic Pathway 100%
• Lifespan 100%
• Histone Deacetylase 100%
• Trehalose 100%
• Transactivation 66%
• Transcription Initiation 66%
• Histone Acetylation 33%
• Acetylation 33%
• Promoter Region 33%
• Repressor 33%
• DNA Damage 33%
• Epigenetics 33%
• Caenorhabditis elegans 33%
• High Throughput Sequencing 33%
• Osmotic Stress 33%

Immunology and Microbiology

• Lifespan 100%
• Histone 100%
• Transactivation 66%
• Transcription Initiation 66%
• Promoter Region 33%
• Repressor Gene 33%
• DNA Damage 33%
• Acetylation 33%
• High Throughput Sequencing 33%
• Caenorhabditis elegans 33%
• Osmotic Stress 33%
• Histone Acetylation 33%