In vivo study of microbubbles as an MR susceptibility contrast agent

Kelvin K. Wong; Ingjye Huang; Young R. Kim; Haiying Tang; Edward S. Yang; Kenneth K. Kwong; Ed X. Wu

doi:10.1002/mrm.20181

In vivo study of microbubbles as an MR susceptibility contrast agent

Kelvin K. Wong, Ingjye Huang, Young R. Kim, Haiying Tang, Edward S. Yang, Kenneth K. Kwong, Ed X. Wu

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The potential application of gas microbubbles as a unique intravascular susceptibility contrast agent for MRI has not been fully explored. In this study, the MR susceptibility effect of an ultrasound microbubble contrast agent, Optison®, was studied with rat liver imaging at 7 T. Optison® suspension in two different doses (0.15 mL/kg and 0.4 mL/kg) was injected into rats, and induced transverse relaxation rate increases (ΔR ₂*) of 29.1 ± 1.6 s^-1 (N = 2) and 61.5 ± 12.9 s^-1 (N = 6), respectively, in liver tissue. Liver uptake of intact albumin microbubbles was observed 10 min after injection. Eight of the 16 rats studied showed no susceptibility enhancement. This is probably attributable to the intravascular microbubble growth due to transmural CO ₂ supersaturation in the cecum and colon in small animals that causes microbubble aggregation and trapping in the inferior vena cava (IVC). In vitro ΔR₂* measurements of Optison® suspension at different concentrations are also reported.

Original language	English (US)
Pages (from-to)	445-452
Number of pages	8
Journal	Magnetic Resonance in Medicine
Volume	52
Issue number	3
DOIs	https://doi.org/10.1002/mrm.20181
State	Published - Sep 2004

Keywords

Drug delivery
Gas bubble
Microbubble
Rat liver
Susceptibility contrast

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Radiological and Ultrasound Technology

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10.1002/mrm.20181

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title = "In vivo study of microbubbles as an MR susceptibility contrast agent",

abstract = "The potential application of gas microbubbles as a unique intravascular susceptibility contrast agent for MRI has not been fully explored. In this study, the MR susceptibility effect of an ultrasound microbubble contrast agent, Optison{\textregistered}, was studied with rat liver imaging at 7 T. Optison{\textregistered} suspension in two different doses (0.15 mL/kg and 0.4 mL/kg) was injected into rats, and induced transverse relaxation rate increases (ΔR 2*) of 29.1 ± 1.6 s-1 (N = 2) and 61.5 ± 12.9 s-1 (N = 6), respectively, in liver tissue. Liver uptake of intact albumin microbubbles was observed 10 min after injection. Eight of the 16 rats studied showed no susceptibility enhancement. This is probably attributable to the intravascular microbubble growth due to transmural CO 2 supersaturation in the cecum and colon in small animals that causes microbubble aggregation and trapping in the inferior vena cava (IVC). In vitro ΔR2* measurements of Optison{\textregistered} suspension at different concentrations are also reported.",

keywords = "Drug delivery, Gas bubble, Microbubble, Rat liver, Susceptibility contrast",

author = "Wong, {Kelvin K.} and Ingjye Huang and Kim, {Young R.} and Haiying Tang and Yang, {Edward S.} and Kwong, {Kenneth K.} and Wu, {Ed X.}",

year = "2004",

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doi = "10.1002/mrm.20181",

language = "English (US)",

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AU - Wong, Kelvin K.

AU - Huang, Ingjye

AU - Kim, Young R.

AU - Tang, Haiying

AU - Yang, Edward S.

AU - Kwong, Kenneth K.

AU - Wu, Ed X.

PY - 2004/9

Y1 - 2004/9

N2 - The potential application of gas microbubbles as a unique intravascular susceptibility contrast agent for MRI has not been fully explored. In this study, the MR susceptibility effect of an ultrasound microbubble contrast agent, Optison®, was studied with rat liver imaging at 7 T. Optison® suspension in two different doses (0.15 mL/kg and 0.4 mL/kg) was injected into rats, and induced transverse relaxation rate increases (ΔR 2*) of 29.1 ± 1.6 s-1 (N = 2) and 61.5 ± 12.9 s-1 (N = 6), respectively, in liver tissue. Liver uptake of intact albumin microbubbles was observed 10 min after injection. Eight of the 16 rats studied showed no susceptibility enhancement. This is probably attributable to the intravascular microbubble growth due to transmural CO 2 supersaturation in the cecum and colon in small animals that causes microbubble aggregation and trapping in the inferior vena cava (IVC). In vitro ΔR2* measurements of Optison® suspension at different concentrations are also reported.

AB - The potential application of gas microbubbles as a unique intravascular susceptibility contrast agent for MRI has not been fully explored. In this study, the MR susceptibility effect of an ultrasound microbubble contrast agent, Optison®, was studied with rat liver imaging at 7 T. Optison® suspension in two different doses (0.15 mL/kg and 0.4 mL/kg) was injected into rats, and induced transverse relaxation rate increases (ΔR 2*) of 29.1 ± 1.6 s-1 (N = 2) and 61.5 ± 12.9 s-1 (N = 6), respectively, in liver tissue. Liver uptake of intact albumin microbubbles was observed 10 min after injection. Eight of the 16 rats studied showed no susceptibility enhancement. This is probably attributable to the intravascular microbubble growth due to transmural CO 2 supersaturation in the cecum and colon in small animals that causes microbubble aggregation and trapping in the inferior vena cava (IVC). In vitro ΔR2* measurements of Optison® suspension at different concentrations are also reported.

KW - Drug delivery

KW - Gas bubble

KW - Microbubble

KW - Rat liver

KW - Susceptibility contrast

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In vivo study of microbubbles as an MR susceptibility contrast agent

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