In vivo study of microbubbles as an MR susceptibility contrast agent

Kelvin K. Wong, Ingjye Huang, Young R. Kim, Haiying Tang, Edward S. Yang, Kenneth K. Kwong, Ed X. Wu

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


The potential application of gas microbubbles as a unique intravascular susceptibility contrast agent for MRI has not been fully explored. In this study, the MR susceptibility effect of an ultrasound microbubble contrast agent, Optison®, was studied with rat liver imaging at 7 T. Optison® suspension in two different doses (0.15 mL/kg and 0.4 mL/kg) was injected into rats, and induced transverse relaxation rate increases (ΔR 2*) of 29.1 ± 1.6 s-1 (N = 2) and 61.5 ± 12.9 s-1 (N = 6), respectively, in liver tissue. Liver uptake of intact albumin microbubbles was observed 10 min after injection. Eight of the 16 rats studied showed no susceptibility enhancement. This is probably attributable to the intravascular microbubble growth due to transmural CO 2 supersaturation in the cecum and colon in small animals that causes microbubble aggregation and trapping in the inferior vena cava (IVC). In vitro ΔR2* measurements of Optison® suspension at different concentrations are also reported.

Original languageEnglish (US)
Pages (from-to)445-452
Number of pages8
JournalMagnetic Resonance in Medicine
Issue number3
StatePublished - Sep 2004


  • Drug delivery
  • Gas bubble
  • Microbubble
  • Rat liver
  • Susceptibility contrast

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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