TY - JOUR
T1 - In vivo receptor imaging with PET and SPET-pitfalls in quantification
AU - Fujita, M.
N1 - Funding Information:
The author would like to thank C. Burger, Ph..D, P. Rudnc,iMS, k Ki.M ojclik,azkMS, yanMd. G ir,odzk MS for providing PMOD version 2.15 and R.B. Innis, MD, Ph. for.Dheplldf isusciso. This nwk or was supported by NARSAD.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2001
Y1 - 2001
N2 - With the development of new tracers, various neurotransmitter receptors can be imaged in humans including extrastriatal dopamine receptors, serotonin receptors and transporters. In most studies, tracer is intravenously administered as a bolus and the measurement is performed under non-equilibrium conditions in which activities in both plasma and brain change dynamically over time. Under these circumstances with complicated changes, enough caution must be paid for the accuracy of the measurement and the interpretation of the results. For example, the crude measurement at one fixed time point is influenced by between-subject differences in clearance and cerebral blood flow. The influence of neurotransmitter levels on the binding of tracer is different between non-equilibrium and equilibrium conditions. This note warns those who are relatively new to this field about the possibilities of misinterpreting imaging results by showing illustrative examples.
AB - With the development of new tracers, various neurotransmitter receptors can be imaged in humans including extrastriatal dopamine receptors, serotonin receptors and transporters. In most studies, tracer is intravenously administered as a bolus and the measurement is performed under non-equilibrium conditions in which activities in both plasma and brain change dynamically over time. Under these circumstances with complicated changes, enough caution must be paid for the accuracy of the measurement and the interpretation of the results. For example, the crude measurement at one fixed time point is influenced by between-subject differences in clearance and cerebral blood flow. The influence of neurotransmitter levels on the binding of tracer is different between non-equilibrium and equilibrium conditions. This note warns those who are relatively new to this field about the possibilities of misinterpreting imaging results by showing illustrative examples.
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U2 - 10.1080/09540260020024178
DO - 10.1080/09540260020024178
M3 - Article
AN - SCOPUS:0035106798
SN - 0954-0261
VL - 13
SP - 34
EP - 39
JO - International Review of Psychiatry
JF - International Review of Psychiatry
IS - 1
ER -